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Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00517426
Recruitment Status : Completed
First Posted : August 17, 2007
Last Update Posted : January 28, 2016
Information provided by (Responsible Party):
Piergiuseppe Agostoni, Centro Cardiologico Monzino

Brief Summary:

To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure.

Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.

Condition or disease Intervention/treatment Phase
Chronic Heart Failure Drug: acetazolamide Phase 4

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Study Start Date : July 2007
Actual Primary Completion Date : July 2011
Actual Study Completion Date : August 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Failure

Arm Intervention/treatment
Experimental: Active Acetazolamide Drug: acetazolamide
i.v. 500 mg of acetazolamide for the acute study and 500 mg of acetazolamide p.o. t.i.d. for two days
Other Name: Diamox

Primary Outcome Measures :
  1. Suppression of periodic breathing [ Time Frame: two days ]

Secondary Outcome Measures :
  1. suppression of sleeping apnea [ Time Frame: two days ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • chronic heart failure in stable clinical condition
  • exercise-induced periodic breathing

Exclusion Criteria:

  • comorbidities
  • NYHA class IV

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00517426

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Centro Cardiologico Monzino, University of Milan
Milan, Italy, 20138
Sponsors and Collaborators
Centro Cardiologico Monzino
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Principal Investigator: Piergiuseppe Agostoni, MD, PhD Centro Cardiologico Monzino

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Responsible Party: Piergiuseppe Agostoni, MD PhD, Centro Cardiologico Monzino Identifier: NCT00517426     History of Changes
Other Study ID Numbers: R77-CCM S79/407
First Posted: August 17, 2007    Key Record Dates
Last Update Posted: January 28, 2016
Last Verified: January 2016
Keywords provided by Piergiuseppe Agostoni, Centro Cardiologico Monzino:
heart failure,
periodic breathing,
Additional relevant MeSH terms:
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Heart Failure
Heart Diseases
Cardiovascular Diseases
Carbonic Anhydrase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Natriuretic Agents
Physiological Effects of Drugs