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Cytokines and Acute Phase Reactants as Markers of Pulmonary Tuberculosis Treatment

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ClinicalTrials.gov Identifier: NCT00517231
Recruitment Status : Withdrawn (The investigator left the research center and the study was not carried out)
First Posted : August 16, 2007
Last Update Posted : July 7, 2015
Sponsor:
Collaborator:
Information provided by:

Study Description
Brief Summary:
Tuberculosis is a highly prevalent chronic infectious disease caused by Mycobacterium tuberculosis. Cytokines are important biological mediators that regulate immune and inflammatory responses against the bacilli, witch include the acute phase response. Besides this, it becomes essential to determine markers of healing lesions, once this is currently carried out based on the clinical, radiological, and negative bacterioscopy.

Condition or disease
Pulmonary Tuberculosis

Detailed Description:
Tuberculosis is a highly prevalent chronic infectious disease caused by Mycobacterium tuberculosis. Cytokines are important biological mediators that regulate immune and inflammatory responses against the bacilli, witch include the acute phase response. Besides this, it becomes essential to determine markers of healing lesions, once this is currently carried out based on the clinical, radiological, and negative bacterioscopy. The propose of this work was to evaluate the production of IFN- γ in cell supernatants of peripheral blood mononuclear cells (PBMC) culture, TNF-α, IL-10 and TGF-b in cell supernatants of monocytes (MO) culture and biochemical (total proteins, albumin, globulin, α-1-acid glycoprotein and C-reactive protein) and hematological (VHS) serum parameters before and after 3 and 6 months of therapy

Study Design

Study Type : Observational
Actual Enrollment : 0 participants
Time Perspective: Prospective
Study Start Date : June 2005
Estimated Primary Completion Date : June 2015
Estimated Study Completion Date : June 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Tuberculosis
U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • diagnosis of Mycobacterium tuberculosis infection

Exclusion Criteria:

  • all other granulomatous or neoplastic diseases
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00517231


Sponsors and Collaborators
UPECLIN HC FM Botucatu Unesp
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Investigators
Principal Investigator: Jussara Marcondes-Machado, PHD Botucatu School of Medicine - Unesp
More Information

ClinicalTrials.gov Identifier: NCT00517231     History of Changes
Other Study ID Numbers: upeclin/HC/FMB-Unesp-pre02
First Posted: August 16, 2007    Key Record Dates
Last Update Posted: July 7, 2015
Last Verified: July 2015

Keywords provided by UPECLIN HC FM Botucatu Unesp:
Pulmonary tuberculosis
Mycobacterium tuberculosis
Cytokines
Acute Phase Response
Treatment

Additional relevant MeSH terms:
Tuberculosis
Tuberculosis, Pulmonary
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Lung Diseases
Respiratory Tract Diseases
Respiratory Tract Infections