The Innate Immune System and Inflammatory Bowel Disease
The study includes individuals with ulcerative colitis, Crohn's disease and healthy controls. The purpose of this study is to examine the innate immune system (IIS) by exposing peripheral blood monocytes to various ligands relevant for stimulation of the IIS and study the immune response. Colonic mucosal samples are examined to find gene expression patterns which may distinguish the two forms of disease from each other and from healthy controls.
The hypothesis is that the innate immune system has responses unique for the disease states, and that the diseases may be differentiated by examination of gene expression patterns in mucosal biopsies.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||The Innate Immune System and Inflammatory Bowel Disease|
- gene expression patterns in mucosal biopsies [ Time Frame: 2 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Intestinal biopsies Plasma/serum Peripheral blood monocytes
|Study Start Date:||June 2007|
|Estimated Study Completion Date:||December 2015|
|Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00516776
|Dept of Cancer Research and Molecular Medicine, NTNU|
|Trondheim, Norway, NO-7489|
|Principal Investigator:||Arne K Sandvik, MD PhD||Norwegian University of Science and Technology|