Relationship of Peritoneal Solute Transport Rate With VEGF in Children Undergoing Peritoneal Dialysis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00516061
Recruitment Status : Unknown
Verified December 2006 by Samsung Medical Center.
Recruitment status was:  Recruiting
First Posted : August 14, 2007
Last Update Posted : August 14, 2007
Information provided by:
Samsung Medical Center

Brief Summary:
Vascular endothelial growth factor(VEGF) appears to play a central role in the process leading to peritoneal angiogenesis and increased level of VEGF may contribute to high peritoneal small-solute transport rate (PSTR) in continuous ambulatory peritoneal dialysis (CAPD) patients in adult. In children, lymphatic absorption of solute is greater than adult. VEGF-C is related to lymphogenesis, but its role in peritoneal solute transport rate is not known. In this study, we evaluated possible relationship between dialysate VEGF and VEGF-C levels and PSTR in children.

Condition or disease
Peritoneal Dialysis

Detailed Description:
There was significant correlation between dialysate VEGF165 and VEGF-C levels and significant correlation was noted between dialysate VEGF165 and PSTR. Interestingly, dialysate VEGF-C levels had significant correlation with PSTR. High PSTR seems to be related to elevated VEGF-C and VEGF.

Study Type : Observational
Estimated Enrollment : 40 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective/Prospective
Study Start Date : December 2006
Estimated Study Completion Date : December 2007

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   1 Year to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • chronic renal failure
  • children
  • peritoneal dialysis

Exclusion Criteria:

  • acute illness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00516061

Contact: Kyung Hoon Paik, M.D. 82-2-3410-1284

Korea, Republic of
Samsung Medical Center Recruiting
Seoul, Korea, Republic of, 135-710
Contact: Kyung Hoon Paik, M.D.    82-2-3410-1284   
Sponsors and Collaborators
Samsung Medical Center
Principal Investigator: Kyung Hoon Paik, M.D. Samsung Medical Center, Sungkyunkwan University School of Medicine Identifier: NCT00516061     History of Changes
Other Study ID Numbers: 2006-12-008
First Posted: August 14, 2007    Key Record Dates
Last Update Posted: August 14, 2007
Last Verified: December 2006