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Relationship of Peritoneal Solute Transport Rate With VEGF in Children Undergoing Peritoneal Dialysis

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ClinicalTrials.gov Identifier: NCT00516061
Recruitment Status : Unknown
Verified December 2006 by Samsung Medical Center.
Recruitment status was:  Recruiting
First Posted : August 14, 2007
Last Update Posted : August 14, 2007
Sponsor:
Information provided by:
Samsung Medical Center

Brief Summary:
Vascular endothelial growth factor(VEGF) appears to play a central role in the process leading to peritoneal angiogenesis and increased level of VEGF may contribute to high peritoneal small-solute transport rate (PSTR) in continuous ambulatory peritoneal dialysis (CAPD) patients in adult. In children, lymphatic absorption of solute is greater than adult. VEGF-C is related to lymphogenesis, but its role in peritoneal solute transport rate is not known. In this study, we evaluated possible relationship between dialysate VEGF and VEGF-C levels and PSTR in children.

Condition or disease
Peritoneal Dialysis

Detailed Description:
There was significant correlation between dialysate VEGF165 and VEGF-C levels and significant correlation was noted between dialysate VEGF165 and PSTR. Interestingly, dialysate VEGF-C levels had significant correlation with PSTR. High PSTR seems to be related to elevated VEGF-C and VEGF.

Study Type : Observational
Estimated Enrollment : 40 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective/Prospective
Study Start Date : December 2006
Estimated Study Completion Date : December 2007




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Ages Eligible for Study:   1 Year to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • chronic renal failure
  • children
  • peritoneal dialysis

Exclusion Criteria:

  • acute illness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00516061


Contacts
Contact: Kyung Hoon Paik, M.D. 82-2-3410-1284 drwhite@skku.edu

Locations
Korea, Republic of
Samsung Medical Center Recruiting
Seoul, Korea, Republic of, 135-710
Contact: Kyung Hoon Paik, M.D.    82-2-3410-1284    drwhite@skku.edu   
Sponsors and Collaborators
Samsung Medical Center
Investigators
Principal Investigator: Kyung Hoon Paik, M.D. Samsung Medical Center, Sungkyunkwan University School of Medicine

ClinicalTrials.gov Identifier: NCT00516061     History of Changes
Other Study ID Numbers: 2006-12-008
First Posted: August 14, 2007    Key Record Dates
Last Update Posted: August 14, 2007
Last Verified: December 2006