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Relationship of Peritoneal Solute Transport Rate With VEGF in Children Undergoing Peritoneal Dialysis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2006 by Samsung Medical Center.
Recruitment status was:  Recruiting
Information provided by:
Samsung Medical Center Identifier:
First received: August 13, 2007
Last updated: NA
Last verified: December 2006
History: No changes posted
Vascular endothelial growth factor(VEGF) appears to play a central role in the process leading to peritoneal angiogenesis and increased level of VEGF may contribute to high peritoneal small-solute transport rate (PSTR) in continuous ambulatory peritoneal dialysis (CAPD) patients in adult. In children, lymphatic absorption of solute is greater than adult. VEGF-C is related to lymphogenesis, but its role in peritoneal solute transport rate is not known. In this study, we evaluated possible relationship between dialysate VEGF and VEGF-C levels and PSTR in children.

Peritoneal Dialysis

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective/Prospective

Further study details as provided by Samsung Medical Center:

Estimated Enrollment: 40
Study Start Date: December 2006
Estimated Study Completion Date: December 2007
Detailed Description:
There was significant correlation between dialysate VEGF165 and VEGF-C levels and significant correlation was noted between dialysate VEGF165 and PSTR. Interestingly, dialysate VEGF-C levels had significant correlation with PSTR. High PSTR seems to be related to elevated VEGF-C and VEGF.

Ages Eligible for Study:   1 Year to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • chronic renal failure
  • children
  • peritoneal dialysis

Exclusion Criteria:

  • acute illness
  Contacts and Locations
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Please refer to this study by its identifier: NCT00516061

Contact: Kyung Hoon Paik, M.D. 82-2-3410-1284

Korea, Republic of
Samsung Medical Center Recruiting
Seoul, Korea, Republic of, 135-710
Contact: Kyung Hoon Paik, M.D.    82-2-3410-1284   
Sponsors and Collaborators
Samsung Medical Center
Principal Investigator: Kyung Hoon Paik, M.D. Samsung Medical Center, Sungkyunkwan University School of Medicine
  More Information Identifier: NCT00516061     History of Changes
Other Study ID Numbers: 2006-12-008
Study First Received: August 13, 2007
Last Updated: August 13, 2007 processed this record on September 25, 2017