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Genetic Abnormalities and Biological Changes of Panic Disorder Patients After Pharmacotherapy

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2007 by Samsung Medical Center.
Recruitment status was:  Recruiting
Information provided by:
Samsung Medical Center Identifier:
First received: August 13, 2007
Last updated: NA
Last verified: August 2007
History: No changes posted
We plan to examine genetic polymorphism of catechol-O-methyltransferase in panic disorder and neurobiological changes of panic disorder patients after 12 weeks of pharmacotherapy with paroxetine. We plan to include 40 panic disorder patients and 40 normal control subjects in this study for 3 years.

Panic Disorder

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Genetic Abnormalities and Changes of Autonomic Nervous System, Serotonin System, and Neuroendocrine System According to Pharmacotherapy in Panic Disorder

Resource links provided by NLM:

Further study details as provided by Samsung Medical Center:

Estimated Enrollment: 80
Study Start Date: January 2006
Estimated Study Completion Date: December 2008
Case: 2
paroxetine treatment group vs. normal control group


Ages Eligible for Study:   20 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Panic disorder

Exclusion Criteria:

  • Other major medical or psychiatric illnesses
  Contacts and Locations
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Please refer to this study by its identifier: NCT00515996

Korea, Republic of
Samsung Medical Center Recruiting
Seoul, Korea, Republic of, 135-710
Contact: Tae Geun Kim, BA    82-2-3410-2975   
Principal Investigator: Bum-Hee Yu, M.D. & Ph.D.         
Sponsors and Collaborators
Samsung Medical Center
Principal Investigator: Bum-Hee Yu, M.D. & Ph.D. Samsung Medical Center, Sungkyunkwan University School of Medicine
  More Information Identifier: NCT00515996     History of Changes
Other Study ID Numbers: C-A6-418-2
Study First Received: August 13, 2007
Last Updated: August 13, 2007

Keywords provided by Samsung Medical Center:
panic disorder
genetic polymorphism

Additional relevant MeSH terms:
Panic Disorder
Pathologic Processes
Anxiety Disorders
Mental Disorders
Serotonin Receptor Agonists
Serotonin Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs processed this record on September 21, 2017