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The Effect of Early Iron Deficiency on Developmental Brain and Behavior in Infants (IDBB)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2007 by Zhejiang University.
Recruitment status was:  Not yet recruiting
Information provided by:
Zhejiang University Identifier:
First received: August 13, 2007
Last updated: NA
Last verified: August 2007
History: No changes posted
The purpose of this project to examine brain functions and behavior related to ID including sensory ,motor, cognitive and social /emotional functioning, and address unanswered questions about brain and behavior impacts of different timing of ID(pre- and /or postnatal ID) in infants.

Condition Intervention
Iron Deficiency
Dietary Supplement: iron

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Zhejiang University:

Study Start Date: September 2007
Estimated Study Completion Date: September 2010
Groups/Cohorts Assigned Interventions
Case: 1
Iron deficient
Dietary Supplement: iron
Control: 2
Iron sufficient

Detailed Description:
Iron deficiency (ID) is the most common single nutrient disorder in the world. Pregnant women and children before pre-school age are at highest risk. Data from animal models provide evidence that early ID affected developing brain in specific regions and functions by varies processes include myelination, dopamine neurotransmitter system, and neurometabolism. These impacts appeared differential at different time of brain development and different brain regions, depending on the timing of ID. The reversibility of these effects also appeared to depend on the timing of ID. This project uses innovative neuropsychologic/ neurophysiologic and behavioral techniques, such as event-related potentials(ERP), ABR and VEP, to study brain functions and behavior related to ID including sensory ,motor, cognitive and social /emotional functioning, and address unanswered questions about brain and behavior impacts of different timing of ID(pre- and /or postnatal ID) in the human infants. This research has the potential to understand reversibility of effects depending on timing of ID and treatment as well as basic understanding of mechanism of impact of ID in human developing brain. It may also have important implications with regard to policy of interventions for different timing of ID, and improve children early development and the quality of population.

Ages Eligible for Study:   up to 36 Months   (Child)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Full- term infants

Exclusion Criteria:

  • Prematures,
  • Perinatal high risk infants(asphyxia,infection etc.),
  • Maternal alcohol,
  • Smoking,
  • Drug abuse,
  • Inherited diseases
  Contacts and Locations
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Please refer to this study by its identifier: NCT00515918

Contact: Jie Shao, M.D +86-571-87061007 ext 2428

China, Zhejiang
Children's Hospital, Zhejiang University School of Medicine Not yet recruiting
Hangzhou, Zhejiang, China, 310003
Contact: Zhengyan Zhao, M.D    +86-571-87061007   
Principal Investigator: Zhengyan Zhao, M.D         
Sub-Investigator: Jie Shao, M.D         
Sponsors and Collaborators
Zhejiang University
Principal Investigator: Zhengyan Zhao, M.D Zhejiang University School of Medicine, Children's Hosp
  More Information Identifier: NCT00515918     History of Changes
Other Study ID Numbers: C030104-30671773
Study First Received: August 13, 2007
Last Updated: August 13, 2007

Keywords provided by Zhejiang University:
Iron deficiency

Additional relevant MeSH terms:
Anemia, Iron-Deficiency
Anemia, Hypochromic
Hematologic Diseases
Iron Metabolism Disorders
Metabolic Diseases
Trace Elements
Growth Substances
Physiological Effects of Drugs processed this record on May 22, 2017