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One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators

This study has been completed.
Information provided by:
University of Zurich Identifier:
First received: August 13, 2007
Last updated: September 14, 2010
Last verified: March 2008

One-lung ventilation; organ protection; volatile anesthetics

One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study:

  1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse?
  2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium.

    • Trial with immunomodulatory product / biological

Condition Intervention
Thoracic Surgery With One-lung Ventilation
Drug: Sevoflurane/propofol

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Lung: One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators After Deflation and Re-expansion of the Lung During Thoracic Surgery

Resource links provided by NLM:

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • One-lung ventilation measurement in the re-ventilated lung after short-period pulmonary collapse [ Time Frame: Sep 07 ]

Estimated Enrollment: 76
Study Start Date: October 2004
Study Completion Date: September 2007
Primary Completion Date: September 2007 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Sevoflurane/propofol

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion criteria:

  • Thoracic surgery (thoracotomy, thoracoscopy) with one-lung ventilation

Exclusion criteria:

  • Immunosuppressive therapy
  • Ongoing inflammatory processes
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Please refer to this study by its identifier: NCT00515905

University Hospital of Zurich
Zurich, Switzerland
Sponsors and Collaborators
University of Zurich
Study Director: 01 Studienregister MasterAdmins UniversitaetsSpital Zuerich
  More Information

Responsible Party: Beatrice Beck-Schimmer, University of Zurich Identifier: NCT00515905     History of Changes
Other Study ID Numbers: StV 20-2004
Study First Received: August 13, 2007
Last Updated: September 14, 2010

Additional relevant MeSH terms:
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Intravenous
Anesthetics, General
Platelet Aggregation Inhibitors
Anesthetics, Inhalation processed this record on May 22, 2017