GPIAG and Leicester Asthma and Dysfunctional Breathing (GLAD) Study: a Randomised Controlled Study (GLAD)
|ClinicalTrials.gov Identifier: NCT00515840|
Recruitment Status : Completed
First Posted : August 14, 2007
Last Update Posted : November 5, 2015
Breathing retraining supervised by a physiotherapist will result in improvements in the quality of life and asthma control of patients treated for asthma in the community with symptoms suggestive of dysfunctional breathing.
To investigate the effects of breathing retraining on clinical and physiological parameters of asthma control, to identify the characteristics of patients who benefit, to perform a health economic evaluation.
|Condition or disease||Intervention/treatment||Phase|
|Asthma Respiratory||Other: Physiotherapist||Phase 3|
- To assess the effect of breathing retraining on asthma-related health status, asthma control and objective indices of asthma severity (bronchial hyper-reactivity (BHR), sputum eosinophilia and nitric oxide production) in patients with symptomatic asthma.
- To compare the relationship between symptoms of dysfunctional breathing (Nijmegen Questionnaire screening score), changes in asthma-related health status and other parameters resulting from breathing retraining
- To explore the relationship between dysfunctional breathing, baseline asthma symptoms, treatment and asthma-related quality of life.
- To estimate the cost effectiveness of the breathing retraining intervention
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||182 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||GPIAG and Leicester Asthma and Dysfunctional Breathing (GLAD) Study: a Randomised Controlled Study|
|Study Start Date :||October 2003|
|Primary Completion Date :||December 2007|
|Study Completion Date :||December 2007|
Sham Comparator: 1
equal time with health care professional (asthma nurse)
Physiotherapist administered breathing retraining programme
- Change in AQLQ scores between intervention and control groups in subjects with positive NQ screening scores 1 month post intervention Change in AQLQ scores between intervention groups of subjects with positive and negative NQ screening scores [ Time Frame: Dec 2006 ]
- Changes in bronchial hyperresponsiveness(PC 20), sputum eosinophil counts and exhaled NO between intervention and control groups in subjects with positive and negative NQ screening scores Change in ACQ Score between the intervention and the control gr [ Time Frame: Dec 2007 ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00515840
|Principal Investigator:||Mike Thomas||University of Aberdeen|