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Explanted Lung Tissues With Pulmonary Fibrosis

This study is currently recruiting participants.
See Contacts and Locations
Verified September 2016 by University of Chicago
Information provided by (Responsible Party):
University of Chicago Identifier:
First received: August 9, 2007
Last updated: September 19, 2016
Last verified: September 2016
The goal of this study is to use the tissues from the explanted lungs in order to better study the cause of pulmonary fibrosis at a cellular level.

Pulmonary Fibrosis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Utilization of Explanted Lungs for Isolation of Tissue Samples and Primary Cell Lines to Study Pulmonary Fibrosis

Resource links provided by NLM:

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • assess fibroblasts and cytokines associated with pulmonary fibrosis [ Time Frame: 12/2013 ]

Biospecimen Retention:   Samples With DNA
explanted lung tissue

Estimated Enrollment: 90
Study Start Date: February 2006
Estimated Study Completion Date: December 2019
Estimated Primary Completion Date: December 2018 (Final data collection date for primary outcome measure)
Detailed Description:

Pulmonary Fibrosis involves scarring of the lung. Gradually, the air sacs of the lungs become replaced by fibrotic tissue. The most current thinking is that the fibrotic process is a reaction to tiny injury to the lung. When the scar forms, the tissue becomes thicker causing a permanent loss of the tissue's ability to carry oxygen into the bloodstream.

We need to obtain lung tissue from patients without pulmonary fibrosis and compare it to lung tissue from patients with pulmonary fibrosis.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Subjects listed for lung transplant

Inclusion Criteria:

  • all patients awaiting lung transplant

Exclusion Criteria:

  • all who will not give consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00515567

Contact: Edward Garrity, MD

United States, Illinois
The University of Chicago Recruiting
Chicago, Illinois, United States, 60637
Contact: Janine Grohar    773-702-6156   
Sponsors and Collaborators
University of Chicago
Principal Investigator: Edward Garrity, MD University of Chicago
  More Information

Responsible Party: University of Chicago Identifier: NCT00515567     History of Changes
Other Study ID Numbers: 14514A
Study First Received: August 9, 2007
Last Updated: September 19, 2016

Keywords provided by University of Chicago:
explanted lungs
pulmonary fibrosis

Additional relevant MeSH terms:
Pulmonary Fibrosis
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases processed this record on September 21, 2017