Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Psychophysical Studies of Cancer Therapy Pain

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2017 by M.D. Anderson Cancer Center
Information provided by (Responsible Party):
M.D. Anderson Cancer Center Identifier:
First received: August 9, 2007
Last updated: March 24, 2017
Last verified: March 2017
The goal of this clinical research study is to improve understanding of the sensory qualities of patients who have pain caused by cancer therapy. This information will add to the understanding of what causes this pain and may lead to better management of the pain. The specific goal is to define the sensory capacity of patients in their area of pain as a consequence of cancer therapy compared to another body area without pain.

Condition Intervention
Advanced Cancer
Other: Sensory Tests

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Psychophysical Studies of Cancer Therapy-Induced Pain: A Feasibility Study

Resource links provided by NLM:

Further study details as provided by M.D. Anderson Cancer Center:

Primary Outcome Measures:
  • Participant Heat + Cold Pain Threshold [ Time Frame: 1 Hour Sensory Testing: Baseline + testing at repeated intervals throughout chemotherapy or at later follow-ups. ]
  • Participant Mechanical Testing Results <Touch Detection Threshold; Sharpness Threshold + Pain Ratings to Needle Probe; Bump Test> [ Time Frame: 1 Hour Sensory Testing: Baseline + testing at repeated intervals throughout chemotherapy or at later follow-ups. ]

Estimated Enrollment: 450
Actual Study Start Date: January 2001
Estimated Study Completion Date: January 2019
Estimated Primary Completion Date: January 2019 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Cancer Therapy-Induced Pain
Patients with advanced cancer entering chemotherapy or have reported pain as a result of cancer treatment.
Other: Sensory Tests
Tests to find the threshold at which perceive stimuli.

Detailed Description:

Study Participation:

Participants will be contacted either before their initiation of chemotherapy or following their referral to pain management service for neuropathic cancer treatment-related pain.

The sensory tests will take about 1 hour to complete. These tests will seek to find the threshold (a measure of sensitivity) at which you perceive stimuli, such as touch, coolness, warmth, hot/cold feeling and pinprick. You will be asked to rate the intensity of each of these stimuli that you perceive to be painful. You will also be asked to rate the intensity of stimuli that are at a fixed intensity above the pain threshold for most people. Your skin temperature using a radiometer, a scan of your fingers and/or toes, grooved peg board, a timed task to place pegs in slots, and pain scale rating will be collected. Each part of the sensory test are optional and will be collected when possible.

You may either be tested at repeated intervals throughout your chemotherapy or at later follow-up dates to check the length of symptoms.

Length of Study:

Your participation will be complete once you have completed all the sensory testing.

This is an investigational study. A total of 450 patients will be enrolled in this study. All will be enrolled at MD Anderson.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients, 18 years or older, with advanced cancer experiencing cancer therapy-induced pain.

Inclusion Criteria:

  1. Since moderate pain, albeit brief, will be induced, this feasibility project will be limited to consenting adults, 18 years old or older, in which there is also a well established QST database.
  2. The subjects must be able to understand the nature of the study and have signed consent.
  3. The patients must either: a) have pain that has developed as a consequence of cancer therapy with either vinca alkaloids, taxanes, bortezomib, thalidomide, platinum-based compounds or ionizing irradiation. OR b) have no pain that has developed as a consequence of cancer therapy, and are just entering chemotherapy with taxanes, vinka alkaloids, bortezomib, thalidomide, or platinum-based compounds
  4. (For Healthy Controls) Willing to participate and have signed an informed consent.

Exclusion Criteria:

  1. Patients who refuse to participate or who are determined incapable of completing the research.
  2. (For Healthy Controls) Receiving anti-coagulants, immunosuppressed or diabetic.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00515060

Contact: Patrick M. Dougherty, PhD 713-745-0438

United States, Texas
University of Texas MD Anderson Cancer Center Recruiting
Houston, Texas, United States, 77030
Principal Investigator: Patrick M. Dougherty, PhD         
Sponsors and Collaborators
M.D. Anderson Cancer Center
Principal Investigator: Patrick M. Dougherty, PhD M.D. Anderson Cancer Center
  More Information

Additional Information:
Responsible Party: M.D. Anderson Cancer Center Identifier: NCT00515060     History of Changes
Other Study ID Numbers: ANS00-339
Study First Received: August 9, 2007
Last Updated: March 24, 2017

Keywords provided by M.D. Anderson Cancer Center:
Advanced Cancer
Therapy-Induced Pain
Pain Threshold
Sensory Tests
Pain processed this record on April 28, 2017