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Study to Investigate Sleep Apnea Patients at Altitude

This study has been completed.
Information provided by:
University of Zurich Identifier:
First received: August 9, 2007
Last updated: May 25, 2010
Last verified: May 2010
The purpose of the study is to investigate the effect of an altitude sojourn on patients with the obstructive sleep apnea syndrome

Condition Intervention
Obstructive Sleep Apnea Syndrome Other: altitude exposure

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Outcomes Assessor)
Official Title: Study to Investigate Sleep Apnea Patients at Altitude

Resource links provided by NLM:

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • Prevalence and severity of sleep disordered breathing [ Time Frame: during altitude sojourn ]

Secondary Outcome Measures:
  • alterations in sleep structure and vigilance; high altitude related illness [ Time Frame: during altitude sojourn ]

Estimated Enrollment: 40
Study Start Date: August 2007
Study Completion Date: October 2007
Primary Completion Date: October 2007 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: altitude exposure
    sojourn at moderate altitude (1860m and 2590m) during 2 days/nights each
Detailed Description:
Previous observations do not allow to draw firm conclusions on the effect of altitude sojourn on sleep, breathing and daytime performance in patients with the obstructive sleep apnea syndrome. Furthermore, the susceptibility of sleep apnea patients to high altitude related illness is not known. Therefore, the purpose is to study untreated patients with obstructive sleep apnea syndrome living at low altitude during a sojourn of a few days at moderate altitude in order to evaluate the physiologic effects of hypobaric hypoxia in these patients. We hypothesize that: 1. Sleep and nocturnal breathing disturbances in untreated OSA patients are more pronounced at moderate altitude compared to low altitude. 2. The increase in sleep related breathing disturbances at moderate altitude is due to an increase in central apnea/hypopnea

Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Obstructive sleep apnea syndrome based on symptoms and a sleep study

Exclusion Criteria:

  • Sleep disorders other than obstructive sleep apnea syndrome
  • Other than mild, stable cardiovascular disease
  • Other than mild lung disease
  • Chronic rhinitis, previous uvulopalatopharyngoplasty
  • Treatment with drugs that affect respiratory center drive
  • Internal, neurologic or psychiatric disease that interferes with sleep quality
  • Previous intolerance to moderate or low altitude < 2600m
  Contacts and Locations
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Please refer to this study by its identifier: NCT00514826

Pulmonary Division, University Hospital Zurich, Switzerland
Zurich, Switzerland, CH-8091
Sponsors and Collaborators
University of Zurich
Study Director: Konrad E. Bloch, MD Pulmonary Division, University Hospital Zurich, Switzerland
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Konrad E. Bloch, Professor, MD, University Hospital of Zurich, Switzerland Identifier: NCT00514826     History of Changes
Other Study ID Numbers: EK1413
Study First Received: August 9, 2007
Last Updated: May 25, 2010

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases processed this record on June 22, 2017