Serial Measurements of Biomarker in Patients With Acute Decompensated Heart Failure
Evaluation of serial measurement of novel biomarker for diagnosis, prognosis or therapy monitoring in patients presenting with acute decompensated heart failure.
Acute Heart Failure
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Prognostic Value of Serial Biomarker Measurements in Patients With ADHF|
- Course of BNP, NT-proBNP, MR-proADM, Copeptin, ST2, hsTnT [ Time Frame: Entry, 6h, 12h, 18h, 24h, 48h, 6 days, discharge ] [ Designated as safety issue: No ]
|Study Start Date:||February 2007|
|Study Completion Date:||December 2014|
|Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Background: Heart failure (HF) is a chronic and progressive illness resulting from a variety of cardiac causes, including ischemic and valvular heart disease, dilatative cardiomyopathy or hypertension. HF may also develop suddenly, particularly as a complication of acute myocardial infarction or as an acute exacerbation in patients with previously compensated chronic HF. Diagnosis and in-hospital management of HF is often demanding and outcome especially regarding rehospitalizations is impaired. Novel biomarker may be very helpful in assessment of diagnosis, prognosis, and severity of HF as well as for treatment monitoring.
Design: Prospective, multicenter observational study Setting: University Hospital Basel, Kantonsspital Aarau, Kantonsspital Luzern, Kantonsspital Wolhusen Patients: Patients with acute HF not requiring ICU admission
Measurement of serial biomarker (BNP, NT-proBNP, MR-proADM, ST2, hs-cTnI and Copeptin) will be performed at presentation, at 6 hours (h), 12h, 18h, 24h, at 48h, at day 6 and at hospital discharge. Follow- up will be performed at 6 Month, 1 year and 2 years.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00514384
|Cantonal Hospital Aarau|
|Aarau, Aargau, Switzerland|
|Wolhusen, Lucerne, Switzerland|
|University Hospital Basel|
|Basel, Switzerland, 4031|
|University Hospital Lucerne|
|Lucerne, Switzerland, 6000|
|Principal Investigator:||Mueller Christian, MD||University Hospital, Basel, Switzerland|