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Interaction Between Anaesthetics and Methylene Blue

This study has been completed.
Information provided by:
University Hospital, Geneva Identifier:
First received: August 7, 2007
Last updated: NA
Last verified: August 2007
History: No changes posted
We hypothesized that pre-treatment with methylene blue could potentiate the effects of general anaesthetic agents in patients undergoing parathyroidectomy

Condition Intervention
Drug: methylene blue

Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Effects of Methylene Blue on Propofol Requirement During Anaesthesia Induction and Surgery

Resource links provided by NLM:

Further study details as provided by University Hospital, Geneva:

Enrollment: 22
Study Start Date: January 2005
Study Completion Date: April 2007
Groups/Cohorts Assigned Interventions
Case: methylene blue Drug: methylene blue methylene blue in 250 ml 5% glucose-saline, administered intravenously approximately 60 min before anaesthesia induction
Control: C Drug: methylene blue methylene blue in 250 ml 5% glucose-saline, administered intravenously approximately 60 min before anaesthesia induction

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients undergoing parathyroidectomy or partial thyroidectomy

Exclusion Criteria:

  • Psychiatric disorders
  • Drug abuse
  • Weight 20% more or less than ideal body weight
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00513032

Service d'Anesthésiologie, Hôpitaux Universitaires de Genève, Rue Micheli-du-Crest
Geneva, Switzerland, CH-1211
Sponsors and Collaborators
University Hospital, Geneva
Principal Investigator: Marc Licker, MD University Hospital, Geneva
  More Information Identifier: NCT00513032     History of Changes
Other Study ID Numbers: 02-081(02-006) 
Study First Received: August 7, 2007
Last Updated: August 7, 2007
Health Authority: Switzerland: Ethikkommission

Keywords provided by University Hospital, Geneva:
anaesthesia induction
methylene blue
General anesthesia

Additional relevant MeSH terms:
Parathyroid Diseases
Endocrine System Diseases
Methylene Blue
Central Nervous System Depressants
Physiological Effects of Drugs
Hypnotics and Sedatives
Anesthetics, Intravenous
Anesthetics, General
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action processed this record on October 21, 2016