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Interaction Between Anaesthetics and Methylene Blue

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00513032
First Posted: August 8, 2007
Last Update Posted: August 8, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University Hospital, Geneva
  Purpose
We hypothesized that pre-treatment with methylene blue could potentiate the effects of general anaesthetic agents in patients undergoing parathyroidectomy

Condition Intervention
Hyperparathyroidism Drug: methylene blue

Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Effects of Methylene Blue on Propofol Requirement During Anaesthesia Induction and Surgery

Resource links provided by NLM:


Further study details as provided by University Hospital, Geneva:

Enrollment: 22
Study Start Date: January 2005
Study Completion Date: April 2007
Groups/Cohorts Assigned Interventions
Case: methylene blue Drug: methylene blue
5mg.kg-1 methylene blue in 250 ml 5% glucose-saline, administered intravenously approximately 60 min before anaesthesia induction
Control: C Drug: methylene blue
5mg.kg-1 methylene blue in 250 ml 5% glucose-saline, administered intravenously approximately 60 min before anaesthesia induction

  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients undergoing parathyroidectomy or partial thyroidectomy

Exclusion Criteria:

  • Psychiatric disorders
  • Drug abuse
  • Weight 20% more or less than ideal body weight
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00513032


Locations
Switzerland
Service d'Anesthésiologie, Hôpitaux Universitaires de Genève, Rue Micheli-du-Crest
Geneva, Switzerland, CH-1211
Sponsors and Collaborators
University Hospital, Geneva
Investigators
Principal Investigator: Marc Licker, MD University Hospital, Geneva
  More Information

ClinicalTrials.gov Identifier: NCT00513032     History of Changes
Other Study ID Numbers: 02-081(02-006)
First Submitted: August 7, 2007
First Posted: August 8, 2007
Last Update Posted: August 8, 2007
Last Verified: August 2007

Keywords provided by University Hospital, Geneva:
propofol
anaesthesia induction
parathyroidectomy
methylene blue
General anesthesia

Additional relevant MeSH terms:
Hyperparathyroidism
Parathyroid Diseases
Endocrine System Diseases
Anesthetics
Propofol
Methylene Blue
Central Nervous System Depressants
Physiological Effects of Drugs
Hypnotics and Sedatives
Anesthetics, Intravenous
Anesthetics, General
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action