Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization
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ClinicalTrials.gov Identifier: NCT00512876
Recruitment Status :
First Posted : August 8, 2007
Results First Posted : July 3, 2013
Last Update Posted : July 22, 2013
Walter Reed Army Medical Center
Massachusetts Eye and Ear Infirmary
Information provided by (Responsible Party):
Michael J. Mines, MD, Walter Reed Army Medical Center
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 74 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
male or female, at least 18 years of age
clinically stable corneal neovascularization
superficial or deep corneal neovascularization that extends farther than 2mm from the limbus
ability to understand and provide informed consent to participate in this study and willingness to follow study instructions and likely to complete all required visits.
Clinical stability - all of the following criterial should be excluded before a corneal neovascularization can be regarded as clinically stable:
current or recent (<3 months) episode of corneal and ocular surface infection (bacterial, viral, fungal, or acanthamoebal)
recent (<3 months) ocular surgery, including cataract surgery, and/or laser of any type in the study eye
recent (<6 months) full thickness or lamellar keratoplasty
recent (<6 months) ocular surface reconstruction, limbal auto or allograft stem cell transplantation, or amniotic membrane transplantation
current or recent (<3 months) use of contact lens or plan to use contact lens (excluding bandage contact lens)
current or recent (<3 months) persistent corneal epithelial defect (of at leat 14 days duration) measuring more than 1mm2
current or recent (<1 month) systemic corticosteroid therapy or periocular corticosteroid injections to the study eye
current or recent (<3 months) intravitreal durg injection to the study eye.
recent (<1 month) change in dose and frequency of topical steroids and/or non-steroidal anti-inflammatory agents
uncontrolled hypertension defined as systolic blood pressure >150 mmHg or diastolic blood pressure of >90 mmHg
history of a thromboembolic event, including myocardial infarction or cerebral vascular accident
patients age 75 or older
history of renal abnormalities
recent (<3 months) or planned surgery
history of coagulation abnormalities, including end stage liver disease or current anticoagulation medication other than aspirin (warfarin, heparin, enoxaparin or similar anticoagulant agent)
all female patients of childbearing potential will be excluded. A female is considered to be of childbearing potential unless she is postmenopausal and without menses for 12 months or without a uterus and/or both ovaries.
any condition (including language barrier) that precludes patient's ability to comply with study requirements including completion of study.
any condition that precludes the patient's ability or an assisting family member's ability to apply the medication drops or to sustain five minutes of pressure on the lacrimal ducts after drop application.
concurrent enrollment in another clinical investigation medicinal product or device study is prohibited.