DNA Array Analysis of Patients With Cervical Cancer
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|ClinicalTrials.gov Identifier: NCT00512551|
Recruitment Status : Completed
First Posted : August 7, 2007
Last Update Posted : November 30, 2017
|Condition or disease||Intervention/treatment|
|Cervical Cancer||Procedure: Tumor Biopsies|
Patients in this study are already scheduled to begin radiation therapy. Researchers will get tumor cells by taking two biopsies of the cervix. The first biopsy of the cervical tumor will be done before any treatment is given. The second biopsy will be performed about 48 hours after the radiation treatment has begun. They will then study the cells in the lab with a new technique for studying gene expression called DNA array, as well as human papillomavirus (HPV) analysis, quantification of apoptosis levels, hematoxylin and eosin staining, and storage of tissue for future research.
The patterns of gene expression in the biopsies will be compared with the success of radiation treatments.
Some of the material will also be stored and used in the future for other research projects.
This is an investigational study. A total of 18 patients will take part in this study. All will be enrolled at UTMDACC.
|Study Type :||Observational|
|Actual Enrollment :||18 participants|
|Official Title:||A Pilot Study of Early Changes in DNA Array Expression Following Chemo-Radiation Treatment of Cervical Cancer|
|Actual Study Start Date :||June 20, 2000|
|Actual Primary Completion Date :||November 20, 2017|
|Actual Study Completion Date :||November 20, 2017|
Cervical cancer tumor biopsy + radiation therapy
Cervical cancer tumor biopsy + radiation therapy.
Procedure: Tumor Biopsies
Biopsies of the cervical tumor performed first before any treatment is given, and the second about 48 hours after radiation treatment has began.
- The goal of this clinical research study is to find out if the expression of certain genes is linked with the response of cervical cancer to radiation. [ Time Frame: 8 Years ]
- Researchers will study a large number of genes located in tumor material to learn this information. [ Time Frame: 8 Years ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00512551
|United States, Texas|
|University of Texas MD Anderson Cancer Center|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Anuja Jhingran, MD||M.D. Anderson Cancer Center|