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Influence of Epidural Analgesia in Elective Laparoscopic Colorectal Resections

This study has been completed.
Triemli Hospital
Information provided by:
University Hospital, Basel, Switzerland Identifier:
First received: August 6, 2007
Last updated: March 9, 2015
Last verified: March 2015
Epidural anaesthesia in open surgery is a effective method for analgesia and has a positive effect on postoperative resolution of ileus. In laparoscopic surgery, the role of epidural surgery is not established. This prospective observational trial evaluates the effect of epidural analgesia in patients undergoing elective, laparoscopic colorectal surgery.

Condition Intervention Phase
Drug: epidural analgesia (Duracain/Fentanyl/Naropin)
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Influence of Epidural Analgesia in Elective Laparoscopic Colorectal Resections

Resource links provided by NLM:

Further study details as provided by University Hospital, Basel, Switzerland:

Primary Outcome Measures:
  • pain (VAS), cramps (VAS) and quantity of analgesics [ Time Frame: 8 days ]

Secondary Outcome Measures:
  • duration of postoperative ileus morbidity [ Time Frame: 6 months ]

Enrollment: 75
Study Start Date: November 2004
Study Completion Date: January 2007
Arms Assigned Interventions
Active Comparator: 1
epidural analgesia
Drug: epidural analgesia (Duracain/Fentanyl/Naropin)
naropin 0.3% or duracain 0.125% + Fentanyl via epidural catheter 4-12 ml/h
No Intervention: 2
traditional analgesia with opioids

Detailed Description:

All patients with elective, laparoscopic colorectal resection between November 2004 and January 2007 were included in the trial. The decision for epidural analgesia was made by the anaesthetist and the patient. Contraindications were previous back surgery, coagulopathy, severe spondylarthrosis and refusal by the patient as contraindications.

Primary outcome was subjective feeling postoperatively, assessed with a VAS for pain and cramps and amount of analgesics used. Secondary outcomes were duration of postoperative bowel dismotility (first flatus, first defecation, first solid food intake) and general and specific morbidity.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • elective laparoscopic colorectal resection

Exclusion Criteria:

  • emergency surgery
  • preoperatively planned stoma formation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00512395

Triemli Hospital
Zurich, Switzerland
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Triemli Hospital
Principal Investigator: Urs Zingg, MD University Hospital, Basel, Switzerland
  More Information Identifier: NCT00512395     History of Changes
Other Study ID Numbers: STZ 13/04 
Study First Received: August 6, 2007
Last Updated: March 9, 2015
Health Authority: Switzerland: Ethikkommission

Keywords provided by University Hospital, Basel, Switzerland:
laparoscopic colorectal surgery
epidural analgesia
pain score
postoperative ileus

Additional relevant MeSH terms:
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Adjuvants, Anesthesia
Anesthetics, Intravenous
Anesthetics, General
Anesthetics, Local processed this record on October 21, 2016