Postoperative Cognitive Dysfunction in Geriatric Patients

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Basel, Switzerland Identifier:
First received: August 6, 2007
Last updated: October 14, 2015
Last verified: October 2015
Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting. This study will investigate the role of these two factors in patients aged 65 or older undergoing elective surgical procedures under general aesthesia. Non-invasive techniques will be used to monitor intraoperative cerebral perfusion and anticholinergic activity in the patient's blood is determined. Data will be compared to those of a young (20-40 year old) group of patients undergoing elective surgical procedures using an identical anesthetic technique. A second control group of healthy volunteers older than 65 will be investigated to quantify practice effects with repeated testing of cognitive functions.

Delirium, Dementia, Amnestic, Cognitive Disorders
Postoperative Complications
Memory Disorders

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Postoperative Cognitive Dysfunction in Geriatric Patients: the Role of Intraoperative Cerebral Perfusion and Perioperative Anticholinergic Medication

Resource links provided by NLM:

Further study details as provided by University Hospital, Basel, Switzerland:

Primary Outcome Measures:
  • Change in cognitive function due to surgery under general aesthesia [ Time Frame: cognitive function measured prior to and after surgery ] [ Designated as safety issue: No ]
    cognitive function measured by Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neurological test battery

Enrollment: 280
Study Start Date: July 2007
Study Completion Date: February 2012
Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Patients aged 65 or older
Patients aged 20 to 40
Control 2
Healthy volunteers aged 65 or older


Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing elective major surgery under general anesthesia

Inclusion Criteria:

  • Elective surgical procedure under general anaesthesia

Exclusion Criteria:

  • History of cerebrovascular disease
  • Mini Mental status <23
  • Cardiac surgery
  • Neurosurgery
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Please refer to this study by its identifier: NCT00512200

Department of Anaesthesia, University Hospital Basel
Basel, Basel-Stadt, Switzerland, 4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Principal Investigator: Luzius A Steiner, MD, Prof. Department of Anaesthesia, University Hospital Basel
  More Information

No publications provided

Responsible Party: University Hospital, Basel, Switzerland Identifier: NCT00512200     History of Changes
Other Study ID Numbers: EK 75/07
Study First Received: August 6, 2007
Last Updated: October 14, 2015
Health Authority: Switzerland: Federal Office of Public Health

Additional relevant MeSH terms:
Cognition Disorders
Delirium, Dementia, Amnestic, Cognitive Disorders
Memory Disorders
Postoperative Complications
Mental Disorders
Nervous System Diseases
Neurobehavioral Manifestations
Neurologic Manifestations
Pathologic Processes
Signs and Symptoms processed this record on November 25, 2015