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Characterizing PAI-1 Modulation on Monocyte Adhesion

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ClinicalTrials.gov Identifier: NCT00512031
Recruitment Status : Terminated (Investigator left institution)
First Posted : August 7, 2007
Last Update Posted : July 18, 2011
Sponsor:
Information provided by:
Vanderbilt University

Brief Summary:
To determine how altering the expression of a gene known as PAI-1 may affect the adhesive capacity of cells that play a critical role in the developement of human atherosclerosis.

Condition or disease
Atherosclerosis

Detailed Description:
The principal aim of this study is to determine if molecular regulation of the human gene PAI-1 alters the migratory properties of human myeloid and endothelial cells sufficiently enough to regulate entry and exit from the vascular space. Human monocyte become the key cellular orchestrators of human atherosclerotic plaque. We believe that a "loss" of PAI-1 activity may promote a pro-atherogenic effect in human vasculature thereby defining a novel atheroprotective effect for PAI-1 when expressed at normal levels in humans. By using RNA interference to achieve PAI-1 gene, we hope to elucidate the mechanistic basis of how PAI-1 regulation may affect human migration within the vasculature.

Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Characterizing the Effects of PAI-1 Modulation on Human Monocyte Function - The Effect of PAI-1 Post-transcriptional Regulation on Human Monocyte Adhesion
Study Start Date : January 2007
Actual Primary Completion Date : July 2011
Actual Study Completion Date : July 2011

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy volunteers
Criteria

Inclusion Criteria:

  • Ages 18-50
  • No current or past medical problems

Exclusion Criteria:

  • Patients taking prescription drugs (hormonal birth control or herbal supplements may be taken)

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00512031


Locations
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232-6300
Sponsors and Collaborators
Vanderbilt University
Investigators
Principal Investigator: Mohan Sathyamoorthy, MD Vanderbilt University

Responsible Party: Mohan Sathyamoorthy, Vanderbilt University
ClinicalTrials.gov Identifier: NCT00512031     History of Changes
Other Study ID Numbers: 070079
First Posted: August 7, 2007    Key Record Dates
Last Update Posted: July 18, 2011
Last Verified: July 2011

Keywords provided by Vanderbilt University:
atherosclerosis
metabolic pathways
monocyte adhesion,

Additional relevant MeSH terms:
Atherosclerosis
Tissue Adhesions
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Cicatrix
Fibrosis
Pathologic Processes