Multiphoton Laser Scanning Microscopy in Cutaneous Optical Pathology
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ClinicalTrials.gov Identifier: NCT00508781
Recruitment Status : Unknown
Verified November 2002 by National Taiwan University Hospital. Recruitment status was: Recruiting
We use multiphoton laser scanning microscopy to observe cutaneous anatomy and pathology. The study aims to compare surgical specimen by conventional pathology slice with the image by non-invasive multiphoton laser scanning microscopy.
Condition or disease
Optical BiopsyCutaneous PathologyDermatopathology
Behavioral: Multiphoton laser image in cutaneous pathology
For skin diseases, the most convincing method for diagnosis to date is surgical biopsy. However, a skin biopsy is an invasive procedure which carries the risk of tissue damage, wound infection and scar formation. To solve the inconvenience from surgical biopsy, multiphoton laser scanning microscopy is a developing, non-invasive method for observing the cutaneous anatomy and pathology. Multiphoton laser scanning microscopy is good in tissue penetration and resolution with less tissue damage. The study aims to compare surgical specimen by conventional pathology slice with the image by non-invasive multiphoton laser scanning microscopy. A good correlation in multiphoton image may serve as optical biopsy for cutaneous pathology and spare the invasive procedure of skin biopsy.
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Ages Eligible for Study:
1 Year to 90 Years (Child, Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients receiving cosmetic surgeries such as removal of moles