The Effects of Two Days of Bedrest on Insulin Resistance in Type 2 Diabetics
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|ClinicalTrials.gov Identifier: NCT00508599|
Recruitment Status : Completed
First Posted : July 30, 2007
Last Update Posted : April 23, 2008
The hypothesis of this study is that bed rest in diabetic patients will result in a deterioration of metabolic control (primarily glucose).
- To determine the change in metabolic control in type 2 diabetic individuals when three days of bed rest is compared to three days of activity;
- To determine the rate of progression of the deterioration in metabolic control and the magnitude of the decrease;
- To assess whether the anticipated deterioration of metabolic control has effects on several parameters of glucose metabolism, including hyperglycemia and hypoglycemia;
- To determine the effects of bed rest on surrogate markers of atherosclerosis, such as plasminogen activator inhibitor 1 (PAI1), C-reactive protein (CRP), and homocysteine.
- To compare the effects of 48 hours of bed rest on orthostatic responses in type 2 diabetic patients, and healthy non-diabetics.
- To make recommendations to the diabetic community to prevent metabolic deterioration during a 3 day hospitalization.
|Condition or disease||Intervention/treatment||Phase|
|Type 2 Diabetes Insulin Resistance||Other: Study 2 (48 hours of complete bed rest)||Not Applicable|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||16 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effect of a 2-Day Bed Rest on Metabolic and Cardiovascular Risk Factors in Type 2 Diabetic Patients|
|Study Start Date :||May 2003|
|Actual Primary Completion Date :||October 2004|
|Actual Study Completion Date :||February 2006|
No Intervention: 1
Study 1 is the control arm in which participants continue with their normal activity.
Study 2 consists of 48 hours of complete bed rest.
Other: Study 2 (48 hours of complete bed rest)
Effects of 48 hours of bed rest on insulin resistance in type 2 diabetic subjects.
- Insulin resistance and orthostatic response [ Time Frame: 48 hours bed rest and 48 hours activity ]
- Change in glucose, insulin, and orthostatic impairment. [ Time Frame: 48 hours of bed rest and 48 hours of Activity ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00508599
|United States, New Mexico|
|University of New Mexico, Clinical Translational Science Center|
|Albuquerque, New Mexico, United States, 87131|
|Principal Investigator:||David S Schade, M.D.||University of New Mexico|