Hemodynamic Parameters in Euthyroid Patients With Thyroid Nodules
The purpose of this study is to determine the relationship of hemodynamic parameters with the level of thyroid hormones and the histological structure of thyroid nodules in euthyroid patients.
|Study Design:||Time Perspective: Prospective|
|Study Completion Date:||December 2007|
Cohort: Patients with normal blood pressure scheduled to have thyroid nodules surgically removed
Patients from group A not receiving any drugs and who lack other pathology, gender and age matched group B1
Cohort: Patients with increased blood pressure scheduled to have thyroid nodules surgically removed
Patients from group B not receiving any drugs and who lack other pathology, gender and age matched group A1
As opposed to widely investigated condition of cardiovascular system in patients with functional disorders of thyroid gland, the relationship between thyroid hormones and hemodynamic parameters in euthyroid patients remains not enough clear.
We detect the parameters of blood pressure and thyroid hormones in euthyroid patients with thyroid nodules directly before planned operation on the thyroid gland.
As the study is carries out directly before operation, that assumes presence of preoperative stress in patients, activity of the sympatho - adrenal system is estimated in addition.
On the one hand, the design of our research will allow to estimate relationship of thyroid hormones with the parameters of blood pressure in conditions of euthyroidism, on the other hand - to investigate features of blood pressure in patients with thyroid nodules.
The research of the patients in the preoperative period will enable to select the group of patients without pathology of cardiovascular system whose increased blood pressure is connected with preoperative stress, that in turn will allow to exclude influence of the pathology of the cardiovascular system on studied correlation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00507897
|Yaroslavl State Medical Academy|
|Yaroslavl, Russian Federation, 150000|
|Study Chair:||Yuriy Alexandrov, Professor||Yaroslavl State Medical Academy|