Almond Dose Response Study.
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|ClinicalTrials.gov Identifier: NCT00507520|
Recruitment Status : Completed
First Posted : July 26, 2007
Last Update Posted : July 26, 2007
|Condition or disease||Intervention/treatment||Phase|
|Hyperlipidemia Diet Therapy Cardiovascular Disease||Procedure: Full dose almonds Procedure: Half dose almonds+half dose muffin Procedure: Full dose whole wheat muffin||Phase 2|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||27 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||The Effect of Almonds on Coronary Heart Disease Risk Factors: Dose Response Study.|
|Study Start Date :||December 1999|
|Actual Study Completion Date :||September 2001|
- Lipids: Total Cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, apolipoproteins B and AI
- Glycemic control: Glucose, insulin, C-peptide (blood and urine).
- Clotting Factors: fibrinogen, tissue plasminogen activator, plasminogen activator inhibitor, urokinase, factor VII and factor VIII.
- Oxidative Stress: Oxidized LDL-C as conjugated dienes in isolated LDL-C fraction, serum carotenoids, vitamin E, vitamin A; 8-hydroxy-2-deoxyguanosine (8-HDG) in isolated blood lymphocytes; malondialdehyde (MDA); urinary isoprostanes.
- Nitric Oxide: Pulmonary (expired air) NO measured as a marker of whole body NO production and olfactory epithelial NO production in perfused nasal air.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00507520
|St. Michael's Hospital|
|Toronto, Ontario, Canada, M5S 2T2|
|Principal Investigator:||David JA Jenkins, MD, PhD||University of Toronto, St. Michael's Hospital|
|Study Director:||Cyril WC Kendall, PhD||University of Toronto, St. Michael's Hospital|