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Postanesthesia Cognitive Recovery and Neuropsychologic Complications

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00507195
Recruitment Status : Unknown
Verified May 2007 by University of Roma La Sapienza.
Recruitment status was:  Recruiting
First Posted : July 26, 2007
Last Update Posted : July 26, 2007
Information provided by:
University of Roma La Sapienza

Brief Summary:
The study proposes to analyze the difference in the rapidity of the recovery of post operative cognition immediately after extubation and 20, 40 and 60 minutes post extubation and neuropsychological complications (delirium) after 48 hours following general anesthesia using a prospective, randomized approach. Patients undergoing any type of surgery with the exception of cranial, cardiac or thoracic surgery can be enrolled in the study.

Condition or disease Intervention/treatment
Anesthesia Recovery Period Delirium, Dementia, Cognitive Disorders Neurobehavioural Manifestation Mental Competency Drug: Hypnotics: propofol, sevoflurane, desflurane,desflurane,midazolam

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 1200 participants
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Post Operative Cognitive Recovery and Neuropsychological Complications After General Anesthesia. A Comparison Between Different Techniques of Anesthesia: A Multi-Center Observational Study
Study Start Date : May 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Anesthesia
U.S. FDA Resources

Intervention Details:
    Drug: Hypnotics: propofol, sevoflurane, desflurane,desflurane,midazolam
    Other Names:
    • Propofol,
    • sevoflurane,
    • desflurane,
    • midazolam

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Adult age patients undergoing general anesthesia

Exclusion Criteria:

  • Cerebral and cardiac surgery
  • Surgical procedures required postoperative delayed extubation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00507195

Contact: Federico Bilotta, MD, PhD 39 339 33 708 22 bilotta@tiscali.it

Azienda Policlinico Umberto I, University of Rome La Sapienza, Recruiting
Rome,, Italy, 00161
Contact: Federico Bilotta, MD, PhD         
Principal Investigator: Federico Bilotta, MD, PhD         
Sponsors and Collaborators
University of Roma La Sapienza
Study Chair: Federico Bilotta, MD, PhD University of Roma La Sapienza

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00507195     History of Changes
Other Study ID Numbers: pinocchio
First Posted: July 26, 2007    Key Record Dates
Last Update Posted: July 26, 2007
Last Verified: May 2007

Keywords provided by University of Roma La Sapienza:
Postanethesia cognitive recovery
Postoperative delirium
postoperative cognitive recovery

Additional relevant MeSH terms:
Cognition Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Intravenous
Anesthetics, General
Adjuvants, Anesthesia
Anti-Anxiety Agents
Tranquilizing Agents
Psychotropic Drugs
GABA Modulators
GABA Agents
Neurotransmitter Agents