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Postanesthesia Cognitive Recovery and Neuropsychologic Complications

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2007 by University of Roma La Sapienza.
Recruitment status was:  Recruiting
Information provided by:
University of Roma La Sapienza Identifier:
First received: July 23, 2007
Last updated: July 24, 2007
Last verified: May 2007
The study proposes to analyze the difference in the rapidity of the recovery of post operative cognition immediately after extubation and 20, 40 and 60 minutes post extubation and neuropsychological complications (delirium) after 48 hours following general anesthesia using a prospective, randomized approach. Patients undergoing any type of surgery with the exception of cranial, cardiac or thoracic surgery can be enrolled in the study.

Condition Intervention
Anesthesia Recovery Period Delirium, Dementia, Cognitive Disorders Neurobehavioural Manifestation Mental Competency Drug: Hypnotics: propofol, sevoflurane, desflurane,desflurane,midazolam

Study Type: Observational
Study Design: Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Post Operative Cognitive Recovery and Neuropsychological Complications After General Anesthesia. A Comparison Between Different Techniques of Anesthesia: A Multi-Center Observational Study

Resource links provided by NLM:

Further study details as provided by University of Roma La Sapienza:

Estimated Enrollment: 1200
Study Start Date: May 2007
Intervention Details:
    Drug: Hypnotics: propofol, sevoflurane, desflurane,desflurane,midazolam
    Other Names:
    • Propofol,
    • sevoflurane,
    • desflurane,
    • midazolam
  Show Detailed Description


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Adult age patients undergoing general anesthesia

Exclusion Criteria:

  • Cerebral and cardiac surgery
  • Surgical procedures required postoperative delayed extubation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00507195

Contact: Federico Bilotta, MD, PhD 39 339 33 708 22

Azienda Policlinico Umberto I, University of Rome La Sapienza, Recruiting
Rome,, Italy, 00161
Contact: Federico Bilotta, MD, PhD         
Principal Investigator: Federico Bilotta, MD, PhD         
Sponsors and Collaborators
University of Roma La Sapienza
Study Chair: Federico Bilotta, MD, PhD University of Roma La Sapienza
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00507195     History of Changes
Other Study ID Numbers: pinocchio
Study First Received: July 23, 2007
Last Updated: July 24, 2007

Keywords provided by University of Roma La Sapienza:
Postanethesia cognitive recovery
Postoperative delirium
postoperative cognitive recovery

Additional relevant MeSH terms:
Cognition Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Intravenous
Anesthetics, General
Adjuvants, Anesthesia
Anti-Anxiety Agents
Tranquilizing Agents
Psychotropic Drugs
GABA Modulators
GABA Agents
Neurotransmitter Agents processed this record on September 21, 2017