Postconditioning in the Treatment of Acute ST-segment Elevation Myocardial Infarction (POSTCON)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00507156|
Recruitment Status : Completed
First Posted : July 25, 2007
Last Update Posted : October 6, 2016
Standard treatment of patients with acute ST-segment elevation myocardial infarction consist of acute re-opening of the occluded coronary artery (primary PCI). Despite successful treatment of the epicardial vessel reperfusion is sometimes inadequate leading to large final infarct sizes. This phenomenon is known as the reperfusion injury. Several animal studies have indicated that graded re-opening of the artery may limit tissue damage. Generally this is referred to as mechanical postconditioning.
The study investigates the effect on final infarct size evaluated by magnetic resonance scan of postconditioning of ST-segment elevation myocardial infarctions. Mechanical postconditioning is performed by means of several balloon inflations in the injured vessel following its acute re-opening.
|Condition or disease||Intervention/treatment||Phase|
|ST-segment Myocardial Infarction||Procedure: Standard primary PCI Procedure: Mechanical postconditioning||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||200 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Postconditioning Used to Limit Final Infarct Size in Patients With Acute ST-segment Elevation Myocardial Infarction|
|Study Start Date :||July 2007|
|Primary Completion Date :||November 2008|
Experimental: Mek postcon
Re-opening of the infarcted coronary artery by several balloon inflations separated by reperfusion of the vessel.
Procedure: Mechanical postconditioning
Mechanical postconditioning with 4 cycles 30/30 sek balloon inflations
Active Comparator: Standard treatment
Standard treatment (primary PCI)
Procedure: Standard primary PCI
Acute re-opening of the occluded coronary artery
- Final infarct size evaluated by MR [ Time Frame: 3 month ]
- MACE (death, re-infarction, TLR) [ Time Frame: 1, 15 month ]
- Stent thrombosis [ Time Frame: 15 month ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00507156
|Cardiac Catherization Lab., Heart Center, Rigshospitalet, University of Copenhagen|
|Copenhagen, Denmark, 2100|
|Study Chair:||Thomas Engstrom, D.Sci., PhD||Cheif Consultant|