Effects of Chronic Sleep Restriction in Young and Older People

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00506428
Recruitment Status : Unknown
Verified April 2009 by National Institute on Aging (NIA).
Recruitment status was:  Recruiting
First Posted : July 25, 2007
Last Update Posted : April 29, 2009
Information provided by:
National Institute on Aging (NIA)

Brief Summary:
The purpose of this study is to examine the consequences of chronic sleep restriction on nighttime sleep, daytime alertness, performance and memory functions, and metabolic and cardiovascular function, and to determine if the consequences of chronic sleep restriction differ between healthy young and older adults.

Condition or disease Intervention/treatment Phase
Aging Sleep Deprivation Metabolic Syndrome Behavioral: chronic sleep restriction Not Applicable

Detailed Description:

It has long been recognized that sleep patterns change with age. A common feature of aging is the advance of the timing of sleep to earlier hours, often earlier than desired. Polysomnographically-recorded sleep in older people shows an increased number of awakenings, a reduction of stages 3 and 4 (SWS) sleep, and a flattening of REM sleep distribution throughout the night. These age-related changes are found in even healthy individuals who are not taking medications and who are free from sleep disorders. In addition to these sleep disturbances, many older individuals curtail their sleep voluntarily, reporting similar rates of sleep restriction (sleeping less than 7 or less than 6 hours per night) as young adults. Whether voluntary or not, insufficient sleep has medical, safety and metabolic consequences. In fact, converging evidence in young adults suggests that sleep restriction per se may impair metabolism, and that reduced sleep duration is associated with weight gain, obesity, diabetes, cardiovascular disease, and mortality.

The study begins with 21 days of outpatient study in which the participants will be required to sleep for 10 hours each night in order to ensure they are well-rested. This will be followed by a 39-day inpatient study. The study will begin with 3 "sleep satiation" days during which all participants will be scheduled to sleep for 12 hours per night and have a 4 hour nap each afternoon. This is followed by 3 baseline days in which the participants will follow the same sleep-wake schedule they were following at home. Following this, the participant will undergo 3 weeks of chronic sleep restriction while living on a non-24-hour schedule. The participant will live on a schedule that is equivalent to 5.6 hours of sleep per 24 hours. Following these 3 weeks, the participant will be scheduled to again sleep for 10 hours per night for 10 nights.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 25 participants
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Official Title: Sleep, Aging, and Circadian Rhythm Disorders
Study Start Date : December 2006
Estimated Primary Completion Date : June 2011
Estimated Study Completion Date : June 2011

Resource links provided by the National Library of Medicine

Intervention Details:
  • Behavioral: chronic sleep restriction
    5.6 hours of sleep per 24 hours for 3 weeks

Primary Outcome Measures :
  1. Changes in sleep and waking EEG measures [ Time Frame: During 3-week chronic sleep restriction segment of inpatient study ]
  2. frequent measures of performance, attention, alertness, and memory [ Time Frame: During 3-week chronic sleep restriction segment of inpatient study ]
  3. measures of cardiovascular and metabolic function [ Time Frame: During 3-week chronic sleep restriction segment of inpatient study ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy

Exclusion Criteria:

  • Chronic or acute medical condition
  • Medication use
  • Depression
  • History of psychiatric illness
  • Sleep disorder

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00506428

United States, Massachusetts
Brigham & Women's Hospital Recruiting
Boston, Massachusetts, United States, 02115
Contact: Tomoko Okada    617-732-7991   
Contact: Sean W Cain, PhD    617-732-5174   
Principal Investigator: Charles A Czeisler, PhD, MD         
Sub-Investigator: Jeanne F Duffy, PhD         
Sub-Investigator: Sean W Cain, PhD         
Sub-Investigator: Orfeu M Buxton, PhD         
Sub-Investigator: Mirjam Munch, PhD         
Sub-Investigator: Daniel Aeschbach, PhD         
Sub-Investigator: Elizabeth B Klerman, MD, PhD         
Sponsors and Collaborators
National Institute on Aging (NIA)
Principal Investigator: Charles A Czeisler, PhD, MD Brigham and Women's Hospital


Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Charles A Czeisler, PhD, MD, Brigham & Women's Hospital Identifier: NCT00506428     History of Changes
Other Study ID Numbers: AG0077
2P01AG009975-11 ( U.S. NIH Grant/Contract )
First Posted: July 25, 2007    Key Record Dates
Last Update Posted: April 29, 2009
Last Verified: April 2009

Keywords provided by National Institute on Aging (NIA):
sleep deprivation

Additional relevant MeSH terms:
Metabolic Syndrome X
Sleep Deprivation
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Sleep Wake Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders