A Longitudinal Study of Osteoarthritis (OA) Disease Progression Measured by MRI, dGEMRIC, and Radiography
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|ClinicalTrials.gov Identifier: NCT00505297|
Recruitment Status : Completed
First Posted : July 23, 2007
Last Update Posted : July 23, 2007
|Condition or disease|
The objective of the study are:
- Evaluate OA progression by evaluating cartilage morphology, cartilage glycosaminoglycan (GAG) content, and joint space changes measured by MRI (3.0T), dGEMRIC index, and radiography, respectively using age-matched control subjects to identify disease related changes.
- Identify subject characteristics associated with more rapidly progressing OA.
- Identify most sensitive efficacy endpoints for future DMOAD proof of concept (POC) studies.
- Establish time interval for future studies based on MRI endpoints.
- Evaluate the effect of contrast agent on MRI cartilage morphology and T2 measurements
- Define criteria for classifying cartilage legions/deficits using dGEMRIC and T2 measurements.
- Collect biofluid samples for future validation of disease specific biomarkers.
|Study Type :||Observational|
|Actual Enrollment :||18 participants|
|Observational Model:||Case Control|
|Observational Model:||Natural History|
|Official Title:||A Longitudinal Study of Osteoarthritis (OA) Disease Progression Measured by MRI, dGEMRIC, and Radiography|
|Study Start Date :||August 2004|
|Actual Study Completion Date :||July 2007|
Subjects with potentiall rapidl progressing OA
Age-matched healthy subjects with no knee pain
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00505297
|United States, California|
|University of California - San Frnacisco|
|San Francisco, California, United States, 94107|
|Principal Investigator:||Sharmila Majumdar, PhD||University of California, San Francisco|
|Principal Investigator:||Thomas M. Link, M.D.||University of California, San Francisco|