Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes
This study involves 90 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine. The subject is given a very low dose of an anesthetic drug intravenously while in the scanner. The subject then sees a sequence of pictures on a screen, and presses a button if they remember seeing the picture before. While this is happening, the scanner will be capturing images that tell us what parts of the brain are active. Hypothesis: patterns of hippocampal and amygdala activation during the encoding and retrieval of memory,as measured by fMRI, will be altered by intravenous anesthetics such that suppression of hippocampal and amygdala activities will be dissociable. This dissociation pattern will be different between the drugs propofol and thiopental
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
|Official Title:||Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes|
- Performance on memory tasks [ Time Frame: 2 hours after MRI ] [ Designated as safety issue: No ]
|Study Start Date:||March 2007|
|Estimated Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Placebo Comparator: A
Drug given in low dose to gauge subject's responses to visual stimuli.
A low dose given intravenously one time for just under an hour while the subject is shown visually stimulating images in an MRI machine.
Placebo Comparator: B
A low dose given intravenously while the subject is shown visually stimulating images in an MRI machine.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00504894
|United States, New York|
|Weill Cornell Medical College|
|New York, New York, United States, 10065|
|Principal Investigator:||Kane Pryor, M.D.||Weill Medical College of Cornell University|