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Lung Disease Collection (Qatar): Evaluation of the Lungs of Individuals With Lung Disease (Q-LD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00504738
Recruitment Status : Completed
First Posted : July 20, 2007
Last Update Posted : April 21, 2015
Sponsor:
Collaborators:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this protocol is to obtain biologic samples from the blood and lungs from patients with lung diseases in order to study the causes and indications of these disorders, learn how these lung disease manifest and progress, and how the lung disease can be treated.

Condition or disease
Lung Disease Chronic Obstructive Pulmonary Disease (COPD) Asthma

Detailed Description:

The lung diseases are disorders associated with functional and/or structural derangements to the alveolar structures, airways, pulmonary blood vessels, pleura and/or mediastinum. The purpose of this protocol is to obtain biologic materials from the blood and lungs from these patients in order to: (1) develop an understanding of the etiology and pathogenesis of these disorders; and (2) identify individuals who will be suitable candidates for other protocols such as those involving investigational new drugs. As such, this protocol is part of the "infrastructure" for all of our human lung-related studies such as genomic/gene expression studies of airway epithelium and alveolar macrophages in all individuals with chronic obstructive lung disease (COPD), asthma, bronchogenic carcinoma, and pulmonary fibrosis compared to normal non-smokers and smokers, and studies of mediators in bronchoalveolar lavage fluid.

This protocol, to be carried out at Weill Cornell Medical College - Qatar and Hamad Medical Corporation, Qatar, parallels a similar approved protocol IRB #0005004440, entitled, "Evaluation of the Lungs of Individuals with Lung Disease with Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy", ongoing at Weill Cornell Medical College - New York.


Study Design

Study Type : Observational
Actual Enrollment : 75 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Evaluation of the Lungs of Individuals With Lung Disease With Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy (Qatar)
Study Start Date : April 2006
Study Completion Date : April 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Lung Diseases
U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Biospecimen Retention:   Samples With DNA
The purpose of this protocol is to obtain biologic samples from the blood and lungs from patients with lung diseases in order to study the causes and indications of these disorders, learn how these lung disease manifest and progress, and how the lung disease can be treated.

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Recruitment will be from the patients of the Hamad Medical Corporation and others as relevant. The source of potential subjects will be the population of potential subjects with lung disease, as defined by the elegibility criteria, in Qatar. Accrual will be random with no bias as to gender or racial/ethnic group.
Criteria

Inclusion Criteria:

Inclusion/Exclusion criteria for Part A

  • Must provide informed consent
  • Males and females, age 18 years and older
  • Evidence of lung disease by at least one of the following:

    1. symptoms consistent with pulmonary disease;
    2. chest X-rays and/or chest CT consistent with lung disease;
    3. pulmonary function tests consistent with lung disease;
    4. lung biopsy consistent with lung disease;
    5. family history of lung disease;
    6. diseases of organs with known association with lung disease; and
    7. individuals suspected of having lung disease based on history and/or physical examination
  • Undergoing fiberoptic bronchoscopy as dictated by their standard clinical care

Exclusion Criteria:

  • Patient refuses consent.

Patients enrolled in Part A of the protocol will not undergo screening procedures/tests. These patients are undergoing a fiberoptic bronchoscopy as dictated by their standard clinical care and additional samples will be taken for research purposes.

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00504738


Locations
Qatar
Hamad Medical Corporation
Doha, Qatar
Sponsors and Collaborators
Weill Medical College of Cornell University
Weill Cornell Medical College in Qatar
Hamad Medical Corporation
Investigators
Principal Investigator: Ronald G. Crystal, MD Weill Cornell Medical College, New York and Qatar
More Information

Responsible Party: Weill Medical College of Cornell University
ClinicalTrials.gov Identifier: NCT00504738     History of Changes
Other Study ID Numbers: 0604008489
HMC RC392/2006 ( Other Identifier: Hamad Medical Corporation )
First Posted: July 20, 2007    Key Record Dates
Last Update Posted: April 21, 2015
Last Verified: April 2015

Keywords provided by Weill Medical College of Cornell University:
lung disease
chronic obstructive pulmonary disease (COPD)
asthma
smokers
non-smokers

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases