Blood Collection From Individuals With Lung Disease for Genetic Studies (Qatar) (Q-BC)
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00504361 |
Recruitment Status :
Completed
First Posted : July 20, 2007
Last Update Posted : May 2, 2016
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease |
---|
Asthma COPD Interstitial Lung Disease Cystic Fibrosis Lung Cancer |
This protocol is designed to collect a small amount of blood for extraction of DNA (genetic material) for the study of the genetic basis of lung disease. The study population will include individuals with known lung diseases and controls without lung disease. Individuals in the study population will be individuals at the Hamad Medical Corporation, Qatar (HMC), as well as other individuals recruited for this study. In this protocol, researchers will survey medical records of patients with chronic lung disease, in order to study the clinical characteristics of these individuals, and the researchers will collect blood to evaluate the genetic characteristics of individuals with chronic lung diseases including asthma, and COPD (chronic obstructive pulmonary disease), pulmonary fibrosis, and lung cancer. The researchers will also collect blood samples of individuals without lung disease to serve as control.
This protocol, to be carried out at Weill Cornell Medical College - Qatar and Hamad Medical Corporation, Qatar, parallels a similar approved protocol IRB #0508008095, entitled, "Collection of Blood for Gene Expression/Genomic Studies in Individuals with Chronic Lung Diseases", ongoing at Weill Cornell Medical College - New York.
Study Type : | Observational |
Actual Enrollment : | 600 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | Collection of Blood for Gene Expression Study in Individuals With Chronic Lung Diseases (Qatar) |
Study Start Date : | May 2006 |
Actual Primary Completion Date : | May 2012 |
Actual Study Completion Date : | May 2012 |

Group/Cohort |
---|
1: Lung Disease
Individuals with at least one of the following: (1) symptoms consistent with pulmonary disease; (2) chest X-ray consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; (6) patients with diseases of organs with known association with lung disease; and (7) individuals suspected of history of lung diseased based on history and/or physical examination
|
2: Normal Control
Individuals without a history of lung disease.
|
- Genomic DNA will be extracted, and genome wide SNP analysis and promoter sequences for genes will be obtained. [ Time Frame: 5 years ]
Biospecimen Retention: Samples With DNA

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years to 90 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Individuals visiting the Medicine Department at the Hamad Medical Corporation, Qatar for standard clinical care will be recruited.
Controls will be obtained from volunteers without a history of lung disease. Family members of patients may be asked to participate in the study.
Lung Disease group. Individuals with lung disease who fit the following criteria will be enrolled.
Inclusion criteria
- Must provide informed consent
- Males and females, age 18 years and older
- Evidence of lung disease proven by at least one of the following: (1) symptoms consistent with pulmonary disease; (2) chest X-rays and/or chest CT consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and (6) diseases of organs with known association with lung disease; and (7) individuals suspected of history of lung diseased based on history and/or physical examination
Exclusion criteria
- Individual refuses consent.
Normal control group. For the purpose of this protocol, "normal" will include individuals without history of chronic lung disease, including asthma, and without recurrent or recent (within 3 months) acute pulmonary disease, and will be determined by the following criteria:
Inclusion Criteria:
- Must provide informed consent.
- Males or females ages 18 years and older.
- Non-smokers, ex-smokers and smokers.
Exclusion Criteria:
- Individual refuses consent.
- Individuals with history of chronic lung disease, including asthma or with recurrent or recent (within three months) acute pulmonary disease will not be accepted into the study.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00504361
Qatar | |
Hamad Medical Corporation | |
Doha, Qatar |
Principal Investigator: | Ronald G Crystal, MD | Weill Cornell Medical College, NY and Qatar |
Responsible Party: | Weill Medical College of Cornell University |
ClinicalTrials.gov Identifier: | NCT00504361 |
Other Study ID Numbers: |
0605008516 HMC RC#373/2006 ( Other Identifier: Hamad Medical Corporation ) |
First Posted: | July 20, 2007 Key Record Dates |
Last Update Posted: | May 2, 2016 |
Last Verified: | April 2016 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | Undecided |
Asthma COPD Interstitial Lung Disease Cystic Fibrosis |
Lung Cancer smokers non-smokers |
Cystic Fibrosis Lung Diseases Lung Diseases, Interstitial Fibrosis Respiratory Tract Diseases |
Pathologic Processes Pancreatic Diseases Digestive System Diseases Genetic Diseases, Inborn Infant, Newborn, Diseases |