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Is There Intravascular Hemolysis in Patients With Pulmonary Hypertension?

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2007 by Rabin Medical Center.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00502398
First Posted: July 17, 2007
Last Update Posted: October 16, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Rabin Medical Center
  Purpose

Patients with hemolytic disorders (e.g. sickle cell anemia or thalassemia) are known to develop pulmonary hypertension. Hemolysis is where red blood cells are destroyed and their contents released into the circulation. It is thought that these red-cell contents cause constriction and thrombosis of the blood vessels in the lungs. Conversely, it is possible that patients with pulmonary hypertension have hemolysis.

In this study we will be drawing blood from a range of patients and normal controls for a panel of blood tests related to hemolysis.


Condition Intervention
Pulmonary Artery Hypertension Procedure: Blood test

Study Type: Observational
Study Design: Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Rabin Medical Center:

Study Start Date: September 2007
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

One of the following four conditions :

  • Pulmonary artery hypertension
  • Obstructive sleep apnea with pulmonary hypertension
  • Lung transplant candidates without pulmonary hypertension
  • Normal Controls

Exclusion Criteria:

  • Known hemolytic disorder
  • Recent blood loss (<3 months)
  • Recent blood transfusion (<3 months)
  • Liver disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00502398


Contacts
Contact: Ben Fox, MRCP +972 3 937 7221 foxb@clalit.org.il

Locations
Israel
Pulmonary Institute, Rabin Medical Center (Beilinson campus) Recruiting
Petach Tikva, Israel, 49100
Contact: Ben Fox, MRCP       foxb@clalit.org.il   
Sponsors and Collaborators
Rabin Medical Center
Investigators
Principal Investigator: Mordechai Kramer, MD Rabin Medical Center
  More Information

ClinicalTrials.gov Identifier: NCT00502398     History of Changes
Other Study ID Numbers: RMC074490CTIL
First Submitted: July 15, 2007
First Posted: July 17, 2007
Last Update Posted: October 16, 2007
Last Verified: October 2007

Additional relevant MeSH terms:
Hypertension
Hypertension, Pulmonary
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases