Neurobiology of Psychogenic Movement Disorder and Non-Epileptic Seizures
This study is part of a series of studies that will explore how the mind and the brain work to cause episodes of uncontrollable shaking in people who have no known underlying brain or medical disorder. The study is conducted at NIH and at the Brown University Rhode Island Hospital.
Healthy volunteers and people with psychogenic movement disorders (PMD) or non-epileptic seizures (NES) who are 18 years of age or older may be eligible for this study.
Patients with NES have 3 teaspoons of blood drawn. The blood is tested for two genes that are normally found in healthy individuals to see if they are found more frequently in patients with uncontrolled shaking.
Patients with PMD have blood drawn for testing and also undergo functional magnetic resonance imaging (fMRI) to look at how the brain functions while the subject performs a specific task. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. During the scan, the subject lies on a table that can slide in and out of the scanner, a metal cylinder. The scan lasts about 60 to 90 minutes, during which the subject may be asked to lie still for up to 10 minutes at a time and to perform tasks, such as identifying the gender of faces shown on a screen.
Healthy volunteers may have blood drawn for genetic testing or fMRI or both.
Psycogenic Movement Disorders
|Study Design:||Time Perspective: Prospective|
|Official Title:||Neurobiological Studies of Psychogenic Movement Disorders and Non-Epileptic Seizures|
|Study Start Date:||July 11, 2007|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00500994
|Contact: Elaine P Considine, R.N.||(301) firstname.lastname@example.org|
|Contact: Carine W Maurer, M.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|United States, Rhode Island|
|Brown University - Rhode Island Hospital||Recruiting|
|Providence, Rhode Island, United States, 02903|
|Principal Investigator:||Carine W Maurer, M.D.||National Institute of Neurological Disorders and Stroke (NINDS)|