Neurobiology of Functional Movement Disorder and Non-Epileptic Seizures
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|ClinicalTrials.gov Identifier: NCT00500994|
Recruitment Status : Recruiting
First Posted : July 13, 2007
Last Update Posted : February 25, 2020
This study is part of a series of studies that will explore how the mind and the brain work to cause episodes of uncontrollable shaking in people who have no known underlying brain or medical disorder. The study is conducted at NIH and at the Brown University Rhode Island Hospital.
Healthy volunteers and people with functional movement disorders (FMD) or non-epileptic seizures (NES) who are 18 years of age or older may be eligible for this study.
Patients with NES have 3 teaspoons of blood drawn. The blood is tested for two genes that are normally found in healthy individuals to see if they are found more frequently in patients with uncontrolled shaking.
Patients with FMD have blood drawn for testing and also undergo functional magnetic resonance imaging (fMRI) to look at how the brain functions while the subject performs a specific task. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. During the scan, the subject lies on a table that can slide in and out of the scanner, a metal cylinder. The scan lasts about 60 to 90 minutes, during which the subject may be asked to lie still for up to 10 minutes at a time and to perform tasks, such as identifying the gender of faces shown on a screen.
Healthy volunteers may have blood drawn for genetic testing or fMRI or both.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||366 participants|
|Official Title:||Neurobiological Studies of Functional Movement Disorders and Non-Epileptic Seizures|
|Actual Study Start Date :||October 5, 2007|
Caregivers of PMD patients
Caregivers of patients diagnosed with PMD who are enrolled in protocol 07-N-0190. A caregiver will be defined as a subject who takes care of the patient for 10 or more hours weekly.
diagnosis of FMD
Age 18 or older, able to give informed consent
diagnosis of PNES
- fMRI BOLD signal change focusing on regions of interest during fear learning task [ Time Frame: throughout protocol ]fMRI BOLD signal change focusing on regions of interest during fear learning task
- fMRI BOLD signal change focusing on regions of interestduring emotional valence task [ Time Frame: throughout protocol ]fMRI BOLD signal change focusing on regions of interest during emotional valence task
- Structural grey matter brain data (VBM) [ Time Frame: throughout protocol ]Structural grey matter brain data (VBM)
- Percent BOLD signal change during interoceptive attention relative to exteroception control condition in dorsal mid-insula [ Time Frame: throughout protocol ]Percent BOLD signal change during interoceptive attention relative to exteroception control condition in dorsal mid-insula
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00500994
|Contact: Elaine P Considine, R.N.||(301) email@example.com|
|Contact: Mark Hallett, M.D.||(301) firstname.lastname@example.org|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 email@example.com|
|United States, Rhode Island|
|Brown University - Rhode Island Hospital||Recruiting|
|Providence, Rhode Island, United States, 02903|
|Principal Investigator:||Mark Hallett, M.D.||National Institute of Neurological Disorders and Stroke (NINDS)|