Influence of Therapeutic Hypothermia on Resting Energy Expenditure
|Cardiopulmonary Resuscitation||Procedure: Measurement of Resting Energy Expenditure|
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Influence of Therapeutic Hypothermia on Resting Energy Expenditure in Patients After Cardiopulmonary Resuscitation|
|Study Start Date:||July 2005|
|Study Completion Date:||May 2008|
|Primary Completion Date:||March 2008 (Final data collection date for primary outcome measure)|
Patients successfully resuscitated after cardiac arrest undergoing therapeutic hypothermia
Procedure: Measurement of Resting Energy Expenditure
Non-invasive measurement of Resting Energy Expenditure
Other Name: Deltatrac (Ohmeda)
Therapeutic hypothermia improves neurologic outcome in patients after cardiopulmonary resuscitation (CPR) because of cardiac arrest. In the present study patients will be cooled to 33 degree Celsius after CPR for 24h. To avoid shivering patients will be analgosedated and medically paralysed. Analgosedation and relaxation have already shown to reduce oxygen consumption up to 20 % in critically ill patients.
In patients with brain injury, who were cooled to 33 degree Celsius using a cooling meadow REE could be significantly reduced. In critically ill patients with pyrexia cooling using a cooling meadow REE could be reduced. Oxygen consumption was reduced about 14,7% per degree Celsius.
So far no studies evaluating influence of therapeutic hypothermia on REE in patients after CPR have been published. Therefore we plan to measure REE in 25 cooled patients after CPR using indirect Calorimetry (Deltatrac II Metabolic Monitor, Datex Instrumentarium, Helsinki, Finland).
Please refer to this study by its ClinicalTrials.gov identifier: NCT00500825
|Medical University Vienna|
|Vienna, Austria, 1090|
|Principal Investigator:||Ulrike Holzinger, MD||Medical University Vienna|