Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) (CP/CPPS)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2011 by Children's Hospital Boston.
Recruitment status was  Recruiting
National Institutes of Health (NIH)
Information provided by:
Children's Hospital Boston Identifier:
First received: July 9, 2007
Last updated: July 21, 2011
Last verified: July 2011

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a condition with several causes of which some remain unknown. It is believed that some types of CP may be genetic and passed down (or inherited) from one generation to the next.

In this study, we are collecting genetic material and medical information to try to determine if there are genetic factors may play a role in CP/CPPS. We will be collecting DNA (from Saliva) and urine from each participant. Individuals and families with CP/CPPS will be enrolled. Family members of an individual with CP/CPPS are eligible whether or not they also experience CP/CPPS symptoms.

Chronic Prostatitis (CP)
Chronic Pelvic Pain Syndrome (CPPS)
Painful Bladder Syndrome (PBS)
Benign Frequency Syndrome (BFS)
Benign Daytime Frequency Syndrome (BDFS)

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Children's Hospital Boston:

Biospecimen Retention:   Samples With DNA
DNA sample via saliva and urine samples will be collected and stored.

Estimated Enrollment: 500
Study Start Date: January 2007
Estimated Study Completion Date: June 2012
Detailed Description:
To further describe the phenotype of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and to correlate the phenotypic information with the genotypic findings utilizing linkage analysis and candidate gene studies. A North American cohort and a Bulgarian cohort will be recruited. Each individual participant will be required to give a DNA sample (via Saliva) and a urine sample. All samples will be stored.

Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We are collecting individuals and families with symptoms and diagnoses of CP/CPPS and their family members (with or without symptoms) from North America (United States and Canada)

Inclusion Criteria:

  • Have symptoms for at least 3 months within the preceding 6 months:
  • Pain in the pelvic area
  • Urinary frequency and/or
  • Urinary urgency and/or
  • Sexual dysfunction (erectile dysfunction)
  • Have CP/CPPS, IC, PBS, or BFS
  • Be willing to provide a saliva and urine sample
  • Agree to complete several brief questionnaires
  • Family member of someone with CP/CPPS, PBS, IC or BFS
  • Live in the USA or Canada

Exclusion Criteria:

  • Major structural/anatomical urinary tract abnormalities
  • Underlying inborn or congenital conditions which affect the urinary tract
  • Surgery/chemotherapy in the pelvic area
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00499317

Contact: Elicia Estrella, MS 617-919-4552
Contact: Stephanie J. Brewster, MS 617-919-4551

United States, Massachusetts
Children's Hospital, Boston Recruiting
Boston, Massachusetts, United States, 02115
Principal Investigator: Louis M Kunkel, PhD         
Sponsors and Collaborators
Children's Hospital Boston
National Institutes of Health (NIH)
Principal Investigator: Jordan Dimitrakov, MD, PhD Children's Hospital Boston
  More Information

Responsible Party: Louis Kunkel, Ph.D., Children's Hospital, Boston Identifier: NCT00499317     History of Changes
Other Study ID Numbers: 04-11-160M 
Study First Received: July 9, 2007
Last Updated: July 21, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by Children's Hospital Boston:
Pelvic pain
Sexual dysfunction
Erectile dysfunction
Painful intercourse

Additional relevant MeSH terms:
Chronic Disease
Cystitis, Interstitial
Pelvic Pain
Disease Attributes
Genital Diseases, Male
Neurologic Manifestations
Pathologic Processes
Prostatic Diseases
Signs and Symptoms
Urinary Bladder Diseases
Urologic Diseases processed this record on May 26, 2016