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Effects of Mild Hypobaric Hypoxia on Sleep and Post-sleep Performance

This study has been completed.
The Boeing Company
Information provided by:
Oklahoma State University Center for Health Sciences Identifier:
First received: July 9, 2007
Last updated: April 22, 2015
Last verified: April 2015
Hypobaric hypoxia (decreased oxygen supply to body tissues due to low atmospheric pressure) caused by exposure to high altitude disrupts sleep. Sleep deprivation is associated with degraded post-sleep performance of neurobehavioral tasks. The lowest altitude at which sleep and/or post-sleep performance are affected is not known. The study hypothesis is that sleep and/or post-sleep performance of neurobehavioral tasks will occur due to hypobaric hypoxia at altitudes of 8,000 or less.

Condition Intervention
Environmental Sleep Disorder
Procedure: altitude exposure in hypobaric chamber

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind
Primary Purpose: Basic Science
Official Title: Investigation to Determine the Effects of Mild Hypobaric Hypoxia on Sleep and Post-Sleep Neurobehavioral Performance

Further study details as provided by Oklahoma State University Center for Health Sciences:

Primary Outcome Measures:
  • Quality and quantity of sleep measured by actigraphy and polysomnography Neurobehavioral performance measured by Psychomotor Vigilance Test (PVT) and Automated Neurophysiologic Assessment Metrics Battery (ANAM) [ Time Frame: 7 hours; 4 hours ]

Secondary Outcome Measures:
  • Mood State measured by Profile of Mood States (POMS) Symptoms of altitude illness measured by Environmental Symptoms Questionnaire (ESQ IV) and Lake Louise Symptom Scores (LLS) [ Time Frame: 20 hours ]

Enrollment: 34
Study Start Date: October 2006
Study Completion Date: August 2007
Primary Completion Date: August 2007 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   30 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy
  • age 30 to 60 years

Exclusion Criteria:

  • sleep disorders or abnormal sleep patterns
  • mood or psychiatric disorders including claustrophobia
  • altitude exposure above 5,000 ft in the previous 2 months
  • born or raised at terrestrial altitude 5,000 ft or greater
  • conditions that would disqualify for FAA Medical Certificate
  • acute medical conditions
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Please refer to this study by its identifier: NCT00498563

United States, Oklahoma
Oklahoma State University Center for Aerospace & Hyperbaric Medicine
Tulsa, Oklahoma, United States, 74132
Sponsors and Collaborators
Oklahoma State University Center for Health Sciences
The Boeing Company
Principal Investigator: J. Michael Muhm, M.D., M.P.H. The Boeing Company
Principal Investigator: Paul B Rock, DO, PhD Oklahoma State University Center for Aerospace & Hyperbaric Medicine
  More Information Identifier: NCT00498563     History of Changes
Other Study ID Numbers: IRB#2006024
Study First Received: July 9, 2007
Last Updated: April 22, 2015

Keywords provided by Oklahoma State University Center for Health Sciences:
high altitude
altitude illness
neurobehavioral manifestations
psychomotor performance
mood states

Additional relevant MeSH terms:
Sleep Wake Disorders
Signs and Symptoms, Respiratory
Signs and Symptoms
Nervous System Diseases
Neurologic Manifestations
Mental Disorders processed this record on May 22, 2017