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Visual Impairment, Oscillopsia and Multiple Sclerosis

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ClinicalTrials.gov Identifier: NCT00498199
Recruitment Status : Terminated
First Posted : July 9, 2007
Last Update Posted : September 30, 2010
Sponsor:
Information provided by:
Hospices Civils de Lyon

Study Description
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Brief Summary:

This study consists of two parts. The first part is a survey to examine vision-specific health-related quality of life in a cohort of patients with multiple sclerosis. We test visual impairment like visual acuity, visual field, colour discrimination, contrast sensitivity, eye movement. The aim of this part is to examine the association between responses to the quality of life scale and objective measures of visual impairment.

The second part is an open controlled study, in which we measure motion detection threshold in MS patients with oscillopsia due to pendular nystagmus and in a group of control subjects. The objective of this part is to determine whether patients with pendular nystagmus develop adaptation to oscillopsia using increased threshold of motion detection. We plan to test the effect of visuo-motor rehabilitation on this threshold in patients with oscillopsia due to pendular nystagmus.


Condition or disease Intervention/treatment
Multiple Sclerosis Procedure: visual tests

Detailed Description:

In the first part, 100 patients with multiple sclerosis are included. A vision-specific health-related quality of life scale and neuro-ophthalmological tests are administered. The duration of intervention is about 3 hours by patient and one year to finish this part.

In the second part, we include about 40 of 100 MS patients who present an oscillopsia due to pendular nystagmus and a group of 20 control subjects. The patients and subject will perform a motion detection task and the vision-specific health-related quality of life, the intervention lasting 1 hour. Then the patients will be randomized in one group treated by rehabilitation (one 30 mn session per week during 3 months) and the other one without treatment. A motion detection task and the vision-specific health-related quality of life scale will be performed at the end of the treatment for both groups.

Study Design
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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Visual Impairment, Oscillopsia and Multiple Sclerosis
Study Start Date : April 2007

Resource links provided by the National Library of Medicine


Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients with established multiple sclerosis
Criteria

Inclusion Criteria:

  • Age 18 to 90
  • Patients with established multiple sclerosis
  • Visual impairment recovering from MS
  • Understanding rules task
  • Patient can stay set a long time
  • Patient's agreement
  • Membership to the Social Security
  • No relapsing since three months

Exclusion Criteria:

  • Brain damage
  • Cognitive or behaviour disorder
  • Patients with peripheral vestibular, otologic or ophthalmologic pathology antecedent
  • Not stabilized disease (other one than MS)
  • Patient under guardianship
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00498199


Locations
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France
Caroline Tilikete
Lyon, France, 69677
Sponsors and Collaborators
Hospices Civils de Lyon
Investigators
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Principal Investigator: Caroline Tilikete, MD Hospices Civils de Lyon
More Information
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ClinicalTrials.gov Identifier: NCT00498199    
Other Study ID Numbers: 2006.432
First Posted: July 9, 2007    Key Record Dates
Last Update Posted: September 30, 2010
Last Verified: July 2007
Keywords provided by Hospices Civils de Lyon:
Multiples sclerosis
oscillopsia
eye movements
 motion detection
retinal slip
nystagmus
Additional relevant MeSH terms:
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Multiple Sclerosis
Vision Disorders
Vision, Low
Sclerosis
Pathologic Processes
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
 Nervous System Diseases
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases
Sensation Disorders
Neurologic Manifestations
Eye Diseases