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Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2010 by University of Leipzig.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00497887
First Posted: July 9, 2007
Last Update Posted: October 19, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Leipzig
  Purpose
Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions. The aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. Atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). Association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.

Condition
Atherosclerosis Coronary Arteriosclerosis Carotid Artery Diseases Genetic Predisposition to Disease Biological Markers

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Observational Study for Identification of Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)

Resource links provided by NLM:


Further study details as provided by University of Leipzig:

Biospecimen Retention:   Samples With DNA
serum, plasma, whole blood (DNA), blood cells

Estimated Enrollment: 4000
Study Start Date: December 2006
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients assigned to coronary angiography
Criteria

Inclusion Criteria:

  • Patients assigned to coronary angiography

Exclusion Criteria:

  • Cancer
  • Acute myocardial infarction
  • Inability to give informed consent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00497887


Contacts
Contact: Joachim Thiery, MD PhD +49-341-9722201 thiery@medizin.uni-leipzig.de
Contact: Gerhard Schuler, MD PhD +49-341-8650 schug@medizin.uni-leipzig.de

Locations
Germany
University of Leipzig, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics Recruiting
Leipzig, Germany, 04103
Contact: Joachim Thiery, MD PhD    +49-341-9722201    thiery@medizin.uni-leipzig.de   
Contact: Daniel Teupser, MD PhD    +49-341-9722204    teupser@medizin.uni-leipzig.de   
Principal Investigator: Joachim Thiery, MD PhD         
Sub-Investigator: Daniel Teupser, MD PhD         
Sub-Investigator: Frank Beutner, MD PhD         
Sub-Investigator: Alexander Leichtle, MD PhD         
Sub-Investigator: Ralph Burkhardt, MD PhD         
Sub-Investigator: Lesca M Holdt, MD PhD         
University of Leipzig, Heart Center, Department of Cardiology Recruiting
Leipzig, Germany, 04289
Contact: Gerhard Schuler, MD PhD    +49-341-8650      
Contact: Stephan Gielen, MD PhD    +49-341-8650      
Principal Investigator: Gerhard Schuler, MD PhD         
Sub-Investigator: Stephan Gielen, MD PhD         
Sub-Investigator: Frank Beutner, MD PhD         
Sub-Investigator: Marcus Sandri, MD PhD         
Sponsors and Collaborators
University of Leipzig
Investigators
Principal Investigator: Joachim Thiery, MD PhD University of Leipzig
  More Information

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Joachim Thiery, Daniel Teupser, Stephan Gielen, Gerhard Schuler, University Leipzig
ClinicalTrials.gov Identifier: NCT00497887     History of Changes
Other Study ID Numbers: 276-2005
First Submitted: July 6, 2007
First Posted: July 9, 2007
Last Update Posted: October 19, 2010
Last Verified: January 2010

Additional relevant MeSH terms:
Atherosclerosis
Arteriosclerosis
Coronary Artery Disease
Myocardial Ischemia
Carotid Artery Diseases
Disease Susceptibility
Genetic Predisposition to Disease
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Coronary Disease
Heart Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Disease Attributes
Pathologic Processes