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Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2010 by University of Leipzig.
Recruitment status was:  Recruiting
Information provided by:
University of Leipzig Identifier:
First received: July 6, 2007
Last updated: October 18, 2010
Last verified: January 2010
Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions. The aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. Atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). Association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.

Coronary Arteriosclerosis
Carotid Artery Diseases
Genetic Predisposition to Disease
Biological Markers

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Observational Study for Identification of Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)

Resource links provided by NLM:

Further study details as provided by University of Leipzig:

Biospecimen Retention:   Samples With DNA
serum, plasma, whole blood (DNA), blood cells

Estimated Enrollment: 4000
Study Start Date: December 2006

Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients assigned to coronary angiography

Inclusion Criteria:

  • Patients assigned to coronary angiography

Exclusion Criteria:

  • Cancer
  • Acute myocardial infarction
  • Inability to give informed consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT00497887

Contact: Joachim Thiery, MD PhD +49-341-9722201
Contact: Gerhard Schuler, MD PhD +49-341-8650

University of Leipzig, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics Recruiting
Leipzig, Germany, 04103
Contact: Joachim Thiery, MD PhD    +49-341-9722201   
Contact: Daniel Teupser, MD PhD    +49-341-9722204   
Principal Investigator: Joachim Thiery, MD PhD         
Sub-Investigator: Daniel Teupser, MD PhD         
Sub-Investigator: Frank Beutner, MD PhD         
Sub-Investigator: Alexander Leichtle, MD PhD         
Sub-Investigator: Ralph Burkhardt, MD PhD         
Sub-Investigator: Lesca M Holdt, MD PhD         
University of Leipzig, Heart Center, Department of Cardiology Recruiting
Leipzig, Germany, 04289
Contact: Gerhard Schuler, MD PhD    +49-341-8650      
Contact: Stephan Gielen, MD PhD    +49-341-8650      
Principal Investigator: Gerhard Schuler, MD PhD         
Sub-Investigator: Stephan Gielen, MD PhD         
Sub-Investigator: Frank Beutner, MD PhD         
Sub-Investigator: Marcus Sandri, MD PhD         
Sponsors and Collaborators
University of Leipzig
Principal Investigator: Joachim Thiery, MD PhD University of Leipzig
  More Information

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Joachim Thiery, Daniel Teupser, Stephan Gielen, Gerhard Schuler, University Leipzig Identifier: NCT00497887     History of Changes
Other Study ID Numbers: 276-2005
Study First Received: July 6, 2007
Last Updated: October 18, 2010

Additional relevant MeSH terms:
Carotid Artery Diseases
Disease Susceptibility
Coronary Artery Disease
Myocardial Ischemia
Genetic Predisposition to Disease
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Disease Attributes
Pathologic Processes
Coronary Disease
Heart Diseases processed this record on May 23, 2017