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Trial record 5 of 8 for:    ATHEROSCLEROSIS SUSCEPTIBILITY

Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2010 by University of Leipzig.
Recruitment status was:  Recruiting
Sponsor:
Information provided by:
University of Leipzig
ClinicalTrials.gov Identifier:
NCT00497887
First received: July 6, 2007
Last updated: October 18, 2010
Last verified: January 2010
  Purpose
Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions. The aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. Atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). Association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.

Condition
Atherosclerosis
Coronary Arteriosclerosis
Carotid Artery Diseases
Genetic Predisposition to Disease
Biological Markers

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Observational Study for Identification of Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)

Resource links provided by NLM:


Further study details as provided by University of Leipzig:

Biospecimen Retention:   Samples With DNA
serum, plasma, whole blood (DNA), blood cells

Estimated Enrollment: 4000
Study Start Date: December 2006
  Eligibility

Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients assigned to coronary angiography
Criteria

Inclusion Criteria:

  • Patients assigned to coronary angiography

Exclusion Criteria:

  • Cancer
  • Acute myocardial infarction
  • Inability to give informed consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00497887

Locations
Germany
University of Leipzig, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics
Leipzig, Germany, 04103
University of Leipzig, Heart Center, Department of Cardiology
Leipzig, Germany, 04289
Sponsors and Collaborators
University of Leipzig
Investigators
Principal Investigator: Joachim Thiery, MD PhD University of Leipzig
  More Information

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Joachim Thiery, Daniel Teupser, Stephan Gielen, Gerhard Schuler, University Leipzig
ClinicalTrials.gov Identifier: NCT00497887     History of Changes
Other Study ID Numbers: 276-2005 
Study First Received: July 6, 2007
Last Updated: October 18, 2010
Health Authority: Germany: Ethics Commission

Additional relevant MeSH terms:
Atherosclerosis
Disease Susceptibility
Genetic Predisposition to Disease
Arteriosclerosis
Carotid Artery Diseases
Coronary Artery Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Coronary Disease
Heart Diseases
Disease Attributes
Pathologic Processes

ClinicalTrials.gov processed this record on December 02, 2016