Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

This study has been completed.
ZonMw: The Netherlands Organisation for Health Research and Development
Information provided by:
Radboud University Identifier:
First received: July 4, 2007
Last updated: September 29, 2008
Last verified: September 2008
A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output. This study assesses the effect of statins on central sympathetic activity in hypertension patients.

Condition Intervention
Drug: atorvastatin 80 mg

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Official Title: Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

Resource links provided by NLM:

Further study details as provided by Radboud University:

Primary Outcome Measures:
  • change in central sympathetic activity

Secondary Outcome Measures:
  • change in cholesterol levels, renin and aldosteron

Estimated Enrollment: 13
Study Start Date: May 2007
Study Completion Date: March 2008

Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • (Known) hypertension
  • stable drug therapy for at least 2 months
  • age 18-70 jaar
  • BMI 18-35 kg/m2
  • Sinusrhythm

Exclusion Criteria:

  • Recent cardiovascular event <6 mnd
  • Plasma Creatinin:
  • female: >120 mmol/L
  • male: >133 mmol/L
  • use of:
  • tricyclic antidepressants
  • alpha-1 -and/or alpha-2 blockers
  • disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc)
  • Albuminuria >300 mg/dag
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00497016

Radboud University Medical Center Nijmegen
NIjmegen, Netherlands, 6500 HB
Sponsors and Collaborators
Radboud University
ZonMw: The Netherlands Organisation for Health Research and Development
Principal Investigator: Cees J Tack, MD, PhD Radboud University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00497016     History of Changes
Other Study ID Numbers: HTSTAT
Study First Received: July 4, 2007
Last Updated: September 29, 2008

Keywords provided by Radboud University:

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases
Atorvastatin Calcium
Anticholesteremic Agents
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Enzyme Inhibitors processed this record on May 23, 2017