Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

This study has been completed.
ZonMw: The Netherlands Organisation for Health Research and Development
Information provided by:
Radboud University Identifier:
First received: July 4, 2007
Last updated: September 29, 2008
Last verified: September 2008
A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output. This study assesses the effect of statins on central sympathetic activity in hypertension patients.

Condition Intervention
Drug: atorvastatin 80 mg

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Official Title: Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

Resource links provided by NLM:

Further study details as provided by Radboud University:

Primary Outcome Measures:
  • change in central sympathetic activity

Secondary Outcome Measures:
  • change in cholesterol levels, renin and aldosteron

Estimated Enrollment: 13
Study Start Date: May 2007
Study Completion Date: March 2008

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both

Inclusion Criteria:

  • (Known) hypertension
  • stable drug therapy for at least 2 months
  • age 18-70 jaar
  • BMI 18-35 kg/m2
  • Sinusrhythm

Exclusion Criteria:

  • Recent cardiovascular event <6 mnd
  • Plasma Creatinin:
  • female: >120 mmol/L
  • male: >133 mmol/L
  • use of:
  • tricyclic antidepressants
  • alpha-1 -and/or alpha-2 blockers
  • disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc)
  • Albuminuria >300 mg/dag
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Please refer to this study by its identifier: NCT00497016

Radboud University Medical Center Nijmegen
NIjmegen, Netherlands, 6500 HB
Sponsors and Collaborators
Radboud University
ZonMw: The Netherlands Organisation for Health Research and Development
Principal Investigator: Cees J Tack, MD, PhD Radboud University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00497016     History of Changes
Other Study ID Numbers: HTSTAT 
Study First Received: July 4, 2007
Last Updated: September 29, 2008
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Radboud University:

Additional relevant MeSH terms:
Cardiovascular Diseases
Vascular Diseases processed this record on April 27, 2016