Effect of Beta Blocker Treatment on Endothelial Function in Patients With Type 2 Diabetes or Chronic Heart Failure
|ClinicalTrials.gov Identifier: NCT00497003|
Recruitment Status : Completed
First Posted : July 6, 2007
Last Update Posted : October 15, 2007
The aim of this study is to evaluate the effect of the two different beta blockers metoprolol and carvedilol on endothelial function in patients with either type two diabetes or chronic heart failure.
Hypothesis: 1* Carvedilol compared to metoprolol has a favourable effect on endothelial function.
2* Carvedilol compared to metoprolol has a favourable effect on insulin stimulated endothelial function.
The study is conducted as an open parallel group study. Endothelial function and insulin stimulated endothelial function was evaluated before and after a two months treatment period with either of the two beta blockers.
|Condition or disease||Intervention/treatment||Phase|
|Endothelial Function Beta Blocker||Drug: Treatment with either metoprolol or carvedilol||Phase 4|
Endothelial function is deteriorated in patients with type 2 diabetes and in patients with chronic heart failure. Treatment with carvedilol improves survival in patients with chronic heart failure compared to treatment with metoprolol. Carvedilol improves metabolic glucose control in patients with diabetes compared to metoprolol.Carvedilol compared to metoprolol also decreases the number of patients with new onset diabetes among patients with chronic heart failure. The mechanism behind these findings has not been fully understood.
The purpose of this study is to investigate if carvedilol compared to metoprolol has a favourable effect on endothelial function and insulin stimulated endothelial function, in groups of patients with either diabetes or chronic heart failure.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||50 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||February 2004|
|Actual Study Completion Date :||October 2007|
- Endothelial function and insulin stimulated endothelial function [ Time Frame: 2 months ]
- Insulin stimulated glucose uptake [ Time Frame: 2 months ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00497003
|Department of Cardiology, University Hospital of Copenhagen, Bispebjerg|
|Copenhagen, Denmark, 2400|
|Principal Investigator:||Christian Torp-Pedersen, MD, DSc||Department of Cardiology, Bispebjerg Hospital|