Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

The Effect of Radiation on Semen Quality and Fertility in Men With Prostate Cancer

This study has been completed.
Information provided by (Responsible Party):
University Health Network, Toronto Identifier:
First received: July 3, 2007
Last updated: December 21, 2015
Last verified: December 2015
Many younger men are diagnosed with prostate cancer. These patients are often choosing radiation therapy as their primary treatment. The effect of this therapy on fertility will have a direct impact on their decision about therapeutic options and fertility preservation. The researchers hypothesize that when patients are treated with radiation for localized prostate cancer, infertility can occur due to direct damage to seminiferous tubules affecting sperm quality.

Prostate Cancer

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Effect of Radiation on Semen Quality and Fertility in Men Treated With External Beam Radiation or Brachytherapy for Early Stage Prostate Cancer

Resource links provided by NLM:

Further study details as provided by University Health Network, Toronto:

Enrollment: 19
Study Start Date: July 2007
Study Completion Date: January 2008
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)
Detailed Description:
Prostate cancer is the most common malignant disease among men. Many young men are diagnosed with localized prostate cancer. Some of these men are choosing to manage their prostate cancer with radiation therapy. The radiation therapy delivers minimal dose exposure to adjacent organs. We hypothesize that when patients are treated with radiation therapy for localized prostate cancer, decreased fertility can occur due to damage of seminiferous tubules, which may affect sperm quality. This study will assess the impact of radiation therapy on semen and seminal fluid.

Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Men being treated with radiation therapy for localized prostate cancer who consent to participate and provide a semen specimen for analysis following thereapy.

Inclusion Criteria:

  • Subjects with histologically confirmed low risk to moderate stage prostate cancer (Gleason 6 - 7) treated with brachytherapy or external beam radiation
  • > 12 months ago

Exclusion Criteria:

  • Subjects with a prior history of infertility
  • Subjects who have undergone vasectomy
  • Subjects who have received LHRH therapy for prostate cancer < 6 months ago
  • Subjects who have received anti-androgens < 3 months ago
  • Subjects using alpha blockers within 7 days of specimen provision
  • Subjects who have taken finasteride or dutasteride within the previous 4 months.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00496249

Canada, Ontario
University Health Network
Toronto, Ontario, Canada, M5G 2M9
Sponsors and Collaborators
University Health Network, Toronto
Principal Investigator: Neil Fleshner, MD University Health Network, Toronto
  More Information

Responsible Party: University Health Network, Toronto Identifier: NCT00496249     History of Changes
Other Study ID Numbers: 07-0197-CE
Study First Received: July 3, 2007
Last Updated: December 21, 2015

Keywords provided by University Health Network, Toronto:

Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Genital Diseases, Male
Prostatic Diseases processed this record on May 25, 2017