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Diagnosis of Ventilator- Associated Pneumonia in Children: A Comparative Study of Bronchoscopic and Non-Bronchoscopic Methods

This study has been completed.
Information provided by:
Sir Ganga Ram Hospital Identifier:
First received: July 2, 2007
Last updated: October 16, 2008
Last verified: July 2007

Background and Objectives: There is a need to validate and suggest easy and less costly diagnostic method for diagnosis of ventilator-associated pneumonia in developing country. The study was performed to compare available methods for the diagnosis and to characterize the organisms causing VAP.

Design and Methods: All patients on mechanical ventilation for more than 48 hours and simplified CPIS ≥ 6 were enrolled prospectively. Four diagnostic procedures, endotracheal aspiration (ETA), blind bronchial sampling (BBS), blind bronchoalveolar lavage (blind BAL) and bronchoscopic BAL (BAL) were performed in same sequence within 12 hours. The bacterial density ≥ 104 cfu/ mL BAL samples were taken as reference standard.

Condition Intervention Phase
Ventilator Associated Pneumonia Procedure: bronchoaleolar lavage Procedure: Bronchoscopy Phase 3

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic

Resource links provided by NLM:

Further study details as provided by Sir Ganga Ram Hospital:

Study Start Date: January 2003
Study Completion Date: September 2003
  Show Detailed Description


Ages Eligible for Study:   up to 12 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Children on mechanical ventilation for more than 72 hours and having simplified clinical pulmonary infection score more than 6 were included in study.

Exclusion Criteria:

  • Age less than 1 month.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00495963

Sir Ganga Ram Hospital
New Delhi, India, 110060
Sponsors and Collaborators
Sir Ganga Ram Hospital
Principal Investigator: Anil Sachdev, MD Sir Ganga Ram Hospital Rajinder Nagar, New Delhi, India
  More Information Identifier: NCT00495963     History of Changes
Other Study ID Numbers: Ehics committee, Sir Ganga Ram
Study First Received: July 2, 2007
Last Updated: October 16, 2008

Keywords provided by Sir Ganga Ram Hospital:
Mechanical ventilation, Ventilator- associated pneumonia, Bronchoalveolar lavage, Pediatric intensive care unit, Flexible bronchoscopy, Critical care

Additional relevant MeSH terms:
Pneumonia, Ventilator-Associated
Lung Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Cross Infection
Ventilator-Induced Lung Injury
Lung Injury processed this record on September 21, 2017