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Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00494689
Recruitment Status : Unknown
Verified June 2007 by Devathasan Neurology Practice Pte Ltd.
Recruitment status was:  Recruiting
First Posted : July 2, 2007
Last Update Posted : July 2, 2007
Information provided by:
Devathasan Neurology Practice Pte Ltd

Brief Summary:
The investigator(neurologist) has published a study in International Congress Series, in the 15th International Conference of Biomagnetism Vancouver Proceedings 2006,and Science Direct website, of 15 patients with brain ischemia and dilated ventricles who improve when treated with transcranial monitoring or low ultrasound wave intensity (milliwatts) and with rapid magnetic stimulation which is also a diagnostic tool routinely used by many neurophysiologists. Before, these patients will progress and may need a brain shunt called Ventriculo-peritoneal shunt. He and collaborators now would like to do a double study as this appears to be a cheap and effective alternative treatment and help patients to walk again.

Condition or disease
Walking Cognitive Function

Detailed Description:

The transcranial monitoring intensity would be equivalent to the well known CLOTBUST study (<300mw/sq cm)for one hour, using two probes.

All will be treated as an outpatient and there is no form of infusion or interventional treatment.

The rapid magnetic stimulation is at about 50a/us, 15Hz, 1000 pulses with 10 sec pause for ten days along the skull vault. Informed consent will be obtained. 30 patients will be recruited and sham treatment would be just applying probe without power for transcranial and for magnetic stimulation coil will be angled away. Data will be compiled by a separate blinded investigator and so with the statistics. VP shunt failure patients, which is common, will be included. Barthel's daily living index and standard cognitive tests will be used to assess results.

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Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Case Control
Time Perspective: Longitudinal
Time Perspective: Prospective
Study Start Date : January 2002
Estimated Study Completion Date : June 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hydrocephalus

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • cerebral ischemia with our without hydrocephalus and gait apraxia

Exclusion Criteria:

  • all other conditions which contribute to walking difficulty e.g. bad knees; or spondylosis; parkinson's or paralytic strokes

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00494689

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Contact: Devathasan Gobinathan, FRCP,MD 65-67330311
Contact: Weng Kiong Ow Yong, Bsc 65-97970966

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Devathasan Neurology Practice #11-16 MEMC Recruiting
Singapore, Singapore, 228510
Principal Investigator: Devathasan Gobinathan, FRCP MD         
Devathasan Neurology Practice Recruiting
Singapore, Singapore, 228510
Contact: Gobinathan Devathasan, FRCP    65-97304401   
Sponsors and Collaborators
Devathasan Neurology Practice Pte Ltd
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Study Chair: Weng Kiong Aw Yong, Bsc (QUT) Freelancer Computer Programmer and data control

Additional Information:
Devathasan G, Dinesh D. Rapid magnetic stimulation with sonolysis for gait apraxia due to to normal pressure hyprocephalus and cerebral ischemia. International Congress Series xx (2007)xxx-xxx( in press)

Layout table for additonal information Identifier: NCT00494689     History of Changes
Other Study ID Numbers: 02
First Posted: July 2, 2007    Key Record Dates
Last Update Posted: July 2, 2007
Last Verified: June 2007
Keywords provided by Devathasan Neurology Practice Pte Ltd:
transcranial sonolysis or monitoring
rapid magnetic stimulation
cerebral ischemia
Barthel's index
Additional relevant MeSH terms:
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Brain Diseases
Central Nervous System Diseases
Nervous System Diseases