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Determination of the Prevalence and Prognostic Importance of Unrecognized Non-Q-wave Myocardial Infarction by MRI

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ClinicalTrials.gov Identifier: NCT00493168
Recruitment Status : Completed
First Posted : June 28, 2007
Last Update Posted : May 27, 2013
Information provided by (Responsible Party):
Duke University

Brief Summary:
The first aim of this study is to determine how often unrecognized myocardial infarction occur in patients using a magnetic resonance imaging (MRI) technique (known as delayed enhancement MRI), as compared to the electrocardiogram. The second aim of this study is to determine the severity of coronary heart disease of the patients with unrecognized myocardial infarction. The final aim is to determine how the presence of unrecognized myocardial infarction detected by the MRI affects lifespan.

Condition or disease
Coronary Arteriosclerosis Myocardial Infarction

Detailed Description:
Unrecognized myocardial infarction (MI) is known to constitute a substantial portion of lethal coronary heart disease. However, since the diagnosis of unrecognized MI is based on the appearance of incidental Q-waves on 12-lead electrocardiography, the syndrome of unrecognized non-Q-wave MI has not been described. Delayed-enhancement cardiovascular magnetic resonance (DE-CMR) can accurately identify non-Q-wave MI. The aims of this study are three-fold: 1. to determine the prevalence of unrecognized non-Q-wave and Q-wave MI, 2. to define predictors of unrecognized non-Q-wave MI, 3. to determine the prognostic significance of unrecognized non-Q-wave MI.

Study Type : Observational
Actual Enrollment : 185 participants
Time Perspective: Prospective
Official Title: Unrecognized Non-Q-wave Myocardial Infarction: Prevalence, Angiographic Correlation, and Prognostic Significance in Patients With Suspected Coronary Disease
Study Start Date : January 1998
Study Completion Date : November 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with suspected coronary artery disease referred for invasive coronary angiography

Exclusion Criteria:

  • Clinical history of myocardial infarction
  • Percutaneous coronary intervention
  • Coronary artery bypass surgery
  • Known uncured malignancy
  • History of hypertrophic cardiomyopathy, myocarditis, or infiltrative heart disease
  • Contraindication of magnetic resonance imaging

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00493168

United States, Illinois
Northwestern University Medical School
Chicago, Illinois, United States, 60611
United States, North Carolina
Duke Cardiovascular Magnetic Resonance Center
Durham, North Carolina, United States, 27710
Sponsors and Collaborators
Duke University
Principal Investigator: Han W Kim, MD Duke Cardiovascular Magnetic Resonance Center
Principal Investigator: Raymond J Kim, MD Duke Cardiovascular Magnetic Resonance Center

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Duke University
ClinicalTrials.gov Identifier: NCT00493168     History of Changes
Other Study ID Numbers: 3434
First Posted: June 28, 2007    Key Record Dates
Last Update Posted: May 27, 2013
Last Verified: June 2007

Additional relevant MeSH terms:
Myocardial Infarction
Coronary Artery Disease
Myocardial Ischemia
Pathologic Processes
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Arterial Occlusive Diseases
Coronary Disease