Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer

This study has been completed.
Information provided by (Responsible Party):
Stanford University Identifier:
First received: June 20, 2007
Last updated: November 24, 2014
Last verified: November 2014

This research involves assessment of cognitive outcome in childhood cancer as well as evaluation of a cognitive rehabilitation program for improving learning and problem solving difficulties in children with cancer.

Condition Intervention
Behavioral: Cognitive rehabilitation
Device: MRI

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer

Resource links provided by NLM:

Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Performance on neuropsychological testing and brain activation patterns measured by functional MRI [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]

Enrollment: 23
Study Start Date: August 2007
Study Completion Date: September 2012
Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cognitive rehabilitation Behavioral: Cognitive rehabilitation
Standard of Care
Other Name: Cognitive rehabilitation therapy
Device: MRI
Standard of Care
Other Name: Magnetic Resonance Imaging

Detailed Description:

The purpose of this study is to help determine specific cognitive-behavioral and neurobiologic impairments associated with chemotherapy treatments in children with cancer and to assess the efficacy of a cognitive intervention program for improving cognitive impairments in these children.


Ages Eligible for Study:   9 Years to 16 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 5 children with any type of cancer in the initial stages of chemotherapy and/or cranial radiation.
  • 10 children with any type of cancer who have completed chemotherapy and cranial radiation.

Exclusion Criteria:

  • Children with pre-cancer/pre-chemotherapy history of brain injury, neurological, psychiatric, neurodevelopmental and/or learning disorders including attention deficit hyperactivity disorder will be excluded.
  • Participants will be excluded for MRI contraindications such as orthodontia and biomedical implants.
  • Non-English speaking participants will be excluded due to the unavailability at this time of translated cognitive testing and MRI assessments.
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Please refer to this study by its identifier: NCT00490334

United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Principal Investigator: Shelli Kesler Stanford University
  More Information

No publications provided

Responsible Party: Stanford University Identifier: NCT00490334     History of Changes
Other Study ID Numbers: PEDSVAR0003, 97817, PEDSVAR0003
Study First Received: June 20, 2007
Last Updated: November 24, 2014
Health Authority: United States: Institutional Review Board

Keywords provided by Stanford University:
Squamous Cel
Acute Lymphocytic Leukemia processed this record on April 16, 2015