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Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer

This study has been completed.
Information provided by (Responsible Party):
Stanford University Identifier:
First received: June 20, 2007
Last updated: May 19, 2015
Last verified: May 2015
This research involves assessment of cognitive outcome in childhood cancer as well as evaluation of a cognitive rehabilitation program for improving learning and problem solving difficulties in children with cancer.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer

Resource links provided by NLM:

Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Performance on neuropsychological testing and brain activation patterns measured by functional MRI [ Time Frame: 8 weeks ]

Enrollment: 72
Study Start Date: August 2007
Study Completion Date: September 2012
Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Cancer patients
Children with cancer aged 8 to 16 years
Control (non-cancer)
Normal children aged 8 to 16 years, age- and gender-matched to the cancer cohort

Detailed Description:
The purpose of this study is to help determine specific cognitive-behavioral and neurobiologic impairments associated with chemotherapy treatments in children with cancer and to assess the efficacy of a cognitive intervention program for improving cognitive impairments in these children.

Ages Eligible for Study:   9 Years to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Pediatric cancer patients 8 to 16 years of age, with age- and gender-matched control group.



  • At least 9 years of age and less than 17 years


  • Diagnosis of brain tumor or acute lymphocytic leukemia (ALL)
  • Completed all anti-cancer treatment(s) including chemotherapy, radiation and/or surgery

Control group

  • Typical for age



  • Non-English speaking (translated cognitive testing and MRI assessments unavailable)
  • MRI contraindication, including but not limited to orthodontia, metal implants, and/or pacemaker
  • Major sensory deficit disorders, including but not limited to blindness or deafness


  • Shunt placement
  • Received bone marrow transplant
  • History of neurologic, psychiatric, developmental or major medical condition (eg, diabetes) NOT related to cancer
  • Participation in any concurrent cognitive rehabilitation study

Control group

  • History of neurologic, psychiatric, developmental or major medical condition (eg, diabetes)
  Contacts and Locations
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Please refer to this study by its identifier: NCT00490334

United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Principal Investigator: Shelli Kesler Stanford University
  More Information

Responsible Party: Stanford University Identifier: NCT00490334     History of Changes
Other Study ID Numbers: IRB-08123
97817 ( Other Identifier: Stanford University Alternate IRB Approval Number )
PEDSVAR0003 ( Other Identifier: OnCore )
Study First Received: June 20, 2007
Last Updated: May 19, 2015

Keywords provided by Stanford University:
Squamous Cel
Acute Lymphocytic Leukemia

Additional relevant MeSH terms:
Cognition Disorders
Neurocognitive Disorders
Mental Disorders processed this record on May 25, 2017