Spontaneous Bacterial Peritonitis: Incidence, Risk Factors and Outcome
Spontaneous bacterial peritonitis (SBP) is a severe complication of ascites in cirrhotic patients. Under clinical experience, this condition seems to be more uncommon in Finland. The aim of this study was to measure the incidence of SBP in consecutive patients with ascites requiring hospitalization in a Finnish University Hospital.
Spontaneous Bacterial Peritonitis
|Study Design:||Observational Model: Defined Population
Time Perspective: Cross-Sectional
|Official Title:||Spontaani Bakterielli Peritoniitti: Esiintyvyys, riskitekijät ja Vaikutus Ennusteeseen|
|Study Start Date:||December 1993|
|Study Completion Date:||March 2007|
Spontaneous bacterial peritonitis (SBP) is a complication of liver cirrhosis with high mortality and low survival rates. The incidence of SBP is reported to range from 11-35% in patients with ascites requiring hospitalization. Under clinical experience, the incidence of SBP in Finland seems to be lower than reported elsewhere. Alcohol is the dominant etiologic factor of liver cirrhosis in Finland (90%), which might be a factor affecting the incidence of SBP. The aim of this study is to measure the incidence of SBP in Finland. We included consecutive patients who underwent diagnostic paracentesis for ascites in Tampere University Hospital during 2/1994 - 12/1998 and 1/2005 - 3/2007. Spontaneous bacterial peritonitis was diagnosed when the ascitic fluid contained over 250 polymorphonuclear cells / mm^3 regardless of culture and with no evidence of intra-abdominal source of infection e.g. an abscess or a perforation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00490217
|Tampere University Hospital|
|Tampere, Pirkanmaa, Finland|
|Principal Investigator:||Jahangir A Khan, MS||Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital|
|Study Director:||Pekka Collin, MD||Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital|
|Study Director:||Pekka Pikkarainen, MD||Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital|