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Periodontal and Periapical Inflammation and Pregnancy

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ClinicalTrials.gov Identifier: NCT00490165
Recruitment Status : Completed
First Posted : June 22, 2007
Last Update Posted : April 6, 2012
Sponsor:
Information provided by (Responsible Party):
Roger Johnson, University of Mississippi Medical Center

Brief Summary:
This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study. Recent animal studies we conducted showed that periapical abscesses during pregnancy cause a systemic inflammatory response in the mother. Also due to the increase in TNF-alpha (an inflammatory cytokine) the mother also become insulin resistant and thus developed gestational diabetes. Periodontal inflammation has been shown in the research to lead to low-birth weight and pre-term birth. We are looking retrospectively to see if an association exists in charted data between periapical and periodontal inflammation and adverse pregnancy outcomes.

Condition or disease
Periodontal Disease Periapical Disease Pregnancy Diabetes Cardiovascular Disease Dental Caries

  Show Detailed Description

Study Type : Observational
Actual Enrollment : 30 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Associations Between Periodontal and Periapical Inflammation and Pregnancy Outcomes
Study Start Date : March 2007
Actual Primary Completion Date : December 2011
Actual Study Completion Date : December 2011




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Ages Eligible for Study:   10 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We are looking at charts of patients (former patients) at the University of Mississippi School of Dentistry. Since this is a pregnancy study we are looking only at the charts of female patients. The youngest record we review is 10 and there is no upper limit to the age.
Criteria

Inclusion Criteria:

  • Female
  • Child bearing age or above

Exclusion Criteria:

  • Male
  • Very young children (before child-bearing age)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00490165


Locations
United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39202
Sponsors and Collaborators
Roger Johnson
Investigators
Principal Investigator: Jennifer L Bain, BS University of Mississippi Medical Center
Study Director: Roger Johnson, PhD; DMD University of Mississippi Medical Center

Responsible Party: Roger Johnson, Professor, University of Mississippi Medical Center
ClinicalTrials.gov Identifier: NCT00490165     History of Changes
Other Study ID Numbers: 2006-0198
First Posted: June 22, 2007    Key Record Dates
Last Update Posted: April 6, 2012
Last Verified: April 2012

Additional relevant MeSH terms:
Inflammation
Cardiovascular Diseases
Dental Caries
Periodontal Diseases
Gingival Diseases
Periapical Diseases
Pathologic Processes
Tooth Demineralization
Tooth Diseases
Stomatognathic Diseases
Mouth Diseases
Jaw Diseases