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Periodontal and Periapical Inflammation and Pregnancy

This study has been completed.
Information provided by (Responsible Party):
Roger Johnson, University of Mississippi Medical Center Identifier:
First received: June 20, 2007
Last updated: April 5, 2012
Last verified: April 2012
This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study. Recent animal studies we conducted showed that periapical abscesses during pregnancy cause a systemic inflammatory response in the mother. Also due to the increase in TNF-alpha (an inflammatory cytokine) the mother also become insulin resistant and thus developed gestational diabetes. Periodontal inflammation has been shown in the research to lead to low-birth weight and pre-term birth. We are looking retrospectively to see if an association exists in charted data between periapical and periodontal inflammation and adverse pregnancy outcomes.

Periodontal Disease
Periapical Disease
Cardiovascular Disease
Dental Caries

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Associations Between Periodontal and Periapical Inflammation and Pregnancy Outcomes

Further study details as provided by University of Mississippi Medical Center:

Enrollment: 30
Study Start Date: March 2007
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   10 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We are looking at charts of patients (former patients) at the University of Mississippi School of Dentistry. Since this is a pregnancy study we are looking only at the charts of female patients. The youngest record we review is 10 and there is no upper limit to the age.

Inclusion Criteria:

  • Female
  • Child bearing age or above

Exclusion Criteria:

  • Male
  • Very young children (before child-bearing age)
  Contacts and Locations
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Please refer to this study by its identifier: NCT00490165

United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39202
Sponsors and Collaborators
Roger Johnson
Principal Investigator: Jennifer L Bain, BS University of Mississippi Medical Center
Study Director: Roger Johnson, PhD; DMD University of Mississippi Medical Center
  More Information

Responsible Party: Roger Johnson, Professor, University of Mississippi Medical Center Identifier: NCT00490165     History of Changes
Other Study ID Numbers: 2006-0198
Study First Received: June 20, 2007
Last Updated: April 5, 2012

Additional relevant MeSH terms:
Cardiovascular Diseases
Dental Caries
Periodontal Diseases
Gingival Diseases
Periapical Diseases
Pathologic Processes
Tooth Demineralization
Tooth Diseases
Stomatognathic Diseases
Mouth Diseases
Jaw Diseases processed this record on May 23, 2017