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Periodontal and Periapical Inflammation and Pregnancy

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00490165
First Posted: June 22, 2007
Last Update Posted: April 6, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Roger Johnson, University of Mississippi Medical Center
  Purpose
This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study. Recent animal studies we conducted showed that periapical abscesses during pregnancy cause a systemic inflammatory response in the mother. Also due to the increase in TNF-alpha (an inflammatory cytokine) the mother also become insulin resistant and thus developed gestational diabetes. Periodontal inflammation has been shown in the research to lead to low-birth weight and pre-term birth. We are looking retrospectively to see if an association exists in charted data between periapical and periodontal inflammation and adverse pregnancy outcomes.

Condition
Periodontal Disease Periapical Disease Pregnancy Diabetes Cardiovascular Disease Dental Caries

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Associations Between Periodontal and Periapical Inflammation and Pregnancy Outcomes

Further study details as provided by Roger Johnson, University of Mississippi Medical Center:

Enrollment: 30
Study Start Date: March 2007
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   10 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We are looking at charts of patients (former patients) at the University of Mississippi School of Dentistry. Since this is a pregnancy study we are looking only at the charts of female patients. The youngest record we review is 10 and there is no upper limit to the age.
Criteria

Inclusion Criteria:

  • Female
  • Child bearing age or above

Exclusion Criteria:

  • Male
  • Very young children (before child-bearing age)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00490165


Locations
United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39202
Sponsors and Collaborators
Roger Johnson
Investigators
Principal Investigator: Jennifer L Bain, BS University of Mississippi Medical Center
Study Director: Roger Johnson, PhD; DMD University of Mississippi Medical Center
  More Information

Responsible Party: Roger Johnson, Professor, University of Mississippi Medical Center
ClinicalTrials.gov Identifier: NCT00490165     History of Changes
Other Study ID Numbers: 2006-0198
First Submitted: June 20, 2007
First Posted: June 22, 2007
Last Update Posted: April 6, 2012
Last Verified: April 2012

Additional relevant MeSH terms:
Inflammation
Cardiovascular Diseases
Dental Caries
Periodontal Diseases
Gingival Diseases
Periapical Diseases
Pathologic Processes
Tooth Demineralization
Tooth Diseases
Stomatognathic Diseases
Mouth Diseases
Jaw Diseases