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Assessment of Pulmonary Involvement inUlcerative Colitis by Induced Sputum

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ClinicalTrials.gov Identifier: NCT00490048
Recruitment Status : Completed
First Posted : June 22, 2007
Last Update Posted : June 22, 2007
Sponsor:
Information provided by:

Study Description
Brief Summary:
Ulcerative colitis is a systemic disease we assume that extra intestinal involvement as we describein our study( Fireman Z, Osipov A, Kivity S, Kopelman Y, Sternberg A Fireman E: Assessment of pulmonary involvement in Crohn’s disease by induced sputum. Am J Gastroenterol 2000;95(30):730-734. )

Condition or disease Intervention/treatment
Ulcerative Colitis Procedure: Induced sputum (inhalation of 3.5% saline)

Detailed Description:
Twenty Ulcerative colitis patients and 20 control subjects (all nonsmokers) without respiratory symptoms will be tested. The induce sputum by 20' inhalation of 3.5% saline using ultrasonic nebulizer. Samples will studied by differential counts of 200 cells on cytopreps stained by Giemsa. T-lymphocyte subset analyses were done by FACS using three monoclonal antibodies: CD3 = total T cells, CD4 = T helper cells, and CD8 = T suppressor-cytotoxic cells. CD4/CD8 >2.5 was considered abnormal.

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Screening
Study Start Date : June 2007
Study Completion Date : June 2007

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U.S. FDA Resources

Arms and Interventions


Outcome Measures

Primary Outcome Measures :
  1. lung involvment in Ulcerative colitis patients

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • All the ulceratvive colitis patients without lung involvmentage 18-75 years of age

Exclusion Criteria:

  • Pregnant women
  • Non cooperative patients
  • Smoker
  • Lung disease
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00490048


Sponsors and Collaborators
Hillel Yaffe Medical Center
Investigators
Principal Investigator: Zvi Fireman, MD Hillel- Yaffe Med. Ctr
More Information

Publications:
ClinicalTrials.gov Identifier: NCT00490048     History of Changes
Other Study ID Numbers: ISUC.CTIL
First Posted: June 22, 2007    Key Record Dates
Last Update Posted: June 22, 2007
Last Verified: June 2007

Keywords provided by Hillel Yaffe Medical Center:
Ulcerative colits
lung
Induced sputum
Our aim to evaluate lung involvement in Ulcerative colitis patients by induced sputum

Additional relevant MeSH terms:
Colitis
Ulcer
Colitis, Ulcerative
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
Colonic Diseases
Intestinal Diseases
Pathologic Processes
Inflammatory Bowel Diseases